代谢变化与免疫和炎症。
Metabolic shifts in immunity and inflammation.
机构信息
Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA.
出版信息
J Immunol. 2010 Apr 15;184(8):4062-8. doi: 10.4049/jimmunol.0903002.
Abstract
Sites of ongoing inflammation and triggered immune responses are characterized by significant changes in metabolic activity. Recent studies have indicated that such shifts in tissue metabolism result from a combination of profound recruitment of inflammatory cells (neutrophils and monocytes) and high proliferation rates among lymphocyte populations. The resultant shifts in energy supply and demand can result in metabolic acidosis and diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to trigger transcriptional and translation changes in tissue phenotype. Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity.
摘要
正在发生炎症和触发免疫反应的部位的代谢活性会发生显著变化。最近的研究表明，组织代谢的这种转变是由于炎症细胞（中性粒细胞和单核细胞）的大量募集以及淋巴细胞群的高增殖率共同作用的结果。由此产生的能量供应和需求的变化可导致代谢性酸中毒以及氧气的输送和/或可用性降低，导致缺氧程度足以引发组织表型的转录和翻译变化。这种表型变化可以对组织代谢产生根本的改变。在本研究中，我们回顾了最近关于炎症和免疫的代谢变化和代谢控制的工作。
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