先天免疫的代谢调控。

Metabolic regulation of innate immunity.

机构信息

Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.

Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

出版信息

Adv Immunol. 2020;145:129-157. doi: 10.1016/bs.ai.2019.11.005. Epub 2019 Dec 5.

DOI:10.1016/bs.ai.2019.11.005

PMID:32081196

Abstract

Immune responses are often accompanied by radical changes of cellular metabolism of immune cells. On the other hand, an ever increasing number of metabolic pathways and products have been found to possess immune regulatory functions. The field of immunometabolism that investigates the interplay between metabolism and immunity has developed rapidly during the past decade. In this chapter, we attempt to summarize the recent progresses by scientists in China on metabolic regulation of innate immunity from the following three perspectives: metabolic regulation of myeloid cell functions, metabolic adaptations of tissue resident myeloid cells, and metabolism and immunity at the mucosal surfaces.

摘要

免疫反应通常伴随着免疫细胞的细胞代谢发生剧烈变化。另一方面，越来越多的代谢途径和产物被发现具有免疫调节功能。在过去十年中，研究代谢与免疫之间相互作用的免疫代谢领域发展迅速。在本章中，我们试图从以下三个方面总结中国科学家在固有免疫代谢调节方面的最新进展：髓样细胞功能的代谢调节、组织驻留髓样细胞的代谢适应以及黏膜表面的代谢和免疫。