Welch Emily J, Jones Brian W, Scott John D
Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Mol Interv. 2010 Apr;10(2):86-97. doi: 10.1124/mi.10.2.6.
A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one cellular location to the next. This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes.
A激酶锚定蛋白(AKAPs)通过将环磷酸腺苷(cAMP)依赖性蛋白激酶(PKA)和其他信号酶 tethering 到细胞器和膜上,来协调和同步细胞活动。对靠近激活剂、效应器和底物的激酶和磷酸酶的控制有利于信息从一个细胞位置快速传播到下一个位置。本文阐述了PKA锚定假说的起源、AKAPs的特性及其命名,以及特定背景下AKAP信号复合物的生理作用。 (注:原文中“tethering”这个词在中文语境下较难准确找到完全对应的简洁词汇,这里保留英文未翻译,可根据具体情况进一步优化表述)