Izbicki J R, Ziegler-Heitbrock H W, Lütticken R, Ruckdeschel G, Wilker D K, Schweiberer L
Chirurgische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Klinikum Innenstadt.
Chirurg. 1991 Mar;62(3):195-200.
The existence of the overwhelming postsplenectomy infection syndrome in adults after traumatic splenectomy is discussed controversially. In this study the effects of splenectomy and spleen-preserving operations on outcome of experimental pneumococcemia of the pig were analyzed. Furthermore, the effect of the monocyte activator MTP-PE was assessed. Splenic operations had no influence on the used criteria of sepsis. Pretreatment with MTP-PE protected animals against development of septic leukocytopenia and led to an enhanced bacterial clearance. In addition, mortality of experimental sepsis was significantly decreased. Splenic preservation in adults after posttraumatic splenectomy does not seem to be warranted. On the other hand, the activator of the monocyte-macrophage-system seems to represent an effective regimen to prevent development of sepsis in high-risk patients.
外伤性脾切除术后成人中压倒性的脾切除后感染综合征的存在存在争议。在本研究中，分析了脾切除术和保脾手术对猪实验性肺炎球菌血症结局的影响。此外，评估了单核细胞激活剂MTP-PE的作用。脾脏手术对所使用的脓毒症标准没有影响。MTP-PE预处理可保护动物免于发生感染性白细胞减少，并导致细菌清除增强。此外，实验性脓毒症的死亡率显著降低。创伤后脾切除术后成人保留脾脏似乎没有必要。另一方面，单核细胞-巨噬细胞系统激活剂似乎是预防高危患者发生脓毒症的有效方案。
