Bagihalli Gangadhar B, Badami Prema S, Patil Sangamesh A
P.G. Department of Chemistry, Karnatak University, Dharwad, Karnataka, India.
J Enzyme Inhib Med Chem. 2009 Apr;24(2):381-94. doi: 10.1080/14756360802187901.
A series of metal complexes of cobalt(II), nickel(II) and copper(II) have been synthesized with newly derived biologically active ligands. These ligands were synthesized by the condensation of 3-substituted-4-amino-5-hydrazino-1,2,4-triazole and 8-formyl-7-hydroxy-4-methylcoumarin. The probable structure of the complexes has been proposed on the basis of elemental analyses and spectral (IR, Uv-Vis, magnetic, ESR, FAB-mass and thermal studies) data. Electro chemical study of the complexes is also reported. All these complexes are non-electrolytes in DMF and DMSO. All the ligands and their Co(II), Ni(II) and Cu(II) complexes were screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Staphylococcus pyogenes and Pseudomonas aeruginosa) and antifungal (Aspergillus niger, Aspergillus flavus and cladosporium) activities by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.
一系列钴（II）、镍（II）和铜（II）的金属配合物已通过新衍生的生物活性配体合成。这些配体是由3-取代-4-氨基-5-肼基-1,2,4-三唑与8-甲酰基-7-羟基-4-甲基香豆素缩合而成。基于元素分析和光谱（红外、紫外可见、磁性、电子顺磁共振、快原子轰击质谱和热分析）数据，提出了配合物的可能结构。还报道了配合物的电化学研究。所有这些配合物在N，N-二甲基甲酰胺和二甲基亚砜中均为非电解质。通过微量肉汤稀释法筛选了所有配体及其钴（II）、镍（II）和铜（II）配合物对大肠杆菌、金黄色葡萄球菌、化脓性葡萄球菌和铜绿假单胞菌的抗菌活性以及对黑曲霉、黄曲霉和枝孢菌的抗真菌活性。还进行了卤虫生物测定以研究它们的体外细胞毒性。
