Department of Adult Psychiatry, Midwestern Regional Hospital, Limerick, Ireland.
Int Psychogeriatr. 2010 Sep;22(6):938-46. doi: 10.1017/S1041610210000475. Epub 2010 Apr 7.
There is uncertainty regarding the optimal use of pharmacological strategies in delirium particularly regarding preferred agents, duration of treatment and effectiveness in different populations.
Attitudes towards delirium pharmacotherapy were investigated before and after an educational workshop using the format of a television game show.
Most respondents (65/66) reported psychotropic use with variable frequency (median 60%). Antipsychotic use was inversely related to perception of supporting evidence (p = 0.02). Respondents rated sedative (38%) and antipsychotic (33%) effects as the principal mechanism of action rather than a specific neurochemical anti-delirium effect (21%). Haloperidol was the preferred first-line agent (65%). Suggested continuation treatment after symptom resolution was three days. Eleven respondents had used psychotropics prophylactically. Antipsychotic use was influenced by concerns regarding potential for extrapyramidal (52%), sedative (32%), cerebrovascular (30%) and metabolic (8%) effects. Post-workshop concerns regarding extrapyramidal effects were reduced with a more positive general attitude towards pharmacological interventions, especially in hypoactive presentations (61%) and prophylactically in high-risk patients (56%).
Attitudes towards key aspects of delirium pharmacotherapy vary considerably and relate to concerns regarding side effect potential more than perceived mechanism of action. Educational interventions can impact positively upon attitudes.
在谵妄的药物治疗中,特别是在选择药物、治疗持续时间和不同人群的疗效方面,药物治疗策略的最佳应用存在不确定性。
采用电视游戏节目的形式,在教育研讨会前后调查了对谵妄药物治疗的态度。
大多数(65/66)受访者报告了精神药物的使用情况,其频率各不相同(中位数为 60%)。抗精神病药物的使用与支持证据的感知呈负相关(p=0.02)。受访者将镇静(38%)和抗精神病(33%)作用评为主要作用机制,而不是特定的神经化学抗谵妄作用(21%)。氟哌啶醇是首选的一线药物(65%)。建议在症状缓解后继续治疗三天。11 名受访者预防性使用了精神药物。抗精神病药物的使用受到潜在的锥体外系(52%)、镇静(32%)、脑血管(30%)和代谢(8%)作用的影响。研讨会后,对锥体外系作用的担忧减少了,对药物干预的总体态度更加积极,尤其是在活动减退型表现(61%)和高危患者预防性使用(56%)的情况下。
对谵妄药物治疗关键方面的态度差异很大,与对潜在副作用的关注多于对潜在作用机制的关注有关。教育干预可以对态度产生积极影响。