Department of Chemistry, University of Rome 'Sapienza', Rome, Italy.
Acta Biomater. 2010 Sep;6(9):3482-90. doi: 10.1016/j.actbio.2010.03.042. Epub 2010 Apr 3.
In recent years the employment of implantable medical devices has increased remarkably, notwithstanding that microbial infections are a frequent complication associated with their use. Different strategies have been attempted to overcome this problem, including the incorporation of antimicrobial agents into the device itself. In this study a new approach to obtain intrinsically antimicrobial materials was developed. Polymer anionomers containing Ag(I), Cu(II), Zn(II), Al(III) and Fe(III) were prepared by neutralization of a carboxylated polyurethane. In the case of the PEUA-Ag, PEUA-Fe and PEUA-Cu ionomers the ion aggregates behaved as reinforcing filler particles, increasing the mechanical properties of the systems in terms of hardness and strength at break over the pristine carboxylated polymer. With the exception of the Al-containing polymer, all the other experimented ionomers showed satisfactory antimicrobial properties. The best antibacterial effect was obtained with the silver ion-containing polymer, which inhibited Staphylococcus epidermidis growth for up to 16days. Ciprofloxacin was also adsorbed onto the above mentioned ionomers. A synergistic effect of the antibiotic and silver ions on bacterial growth inhibition was observed for at least 25days.
近年来，尽管植入式医疗器械的使用与微生物感染密切相关，但它们的应用显著增加。为了解决这个问题，已经尝试了不同的策略，包括将抗菌剂纳入器械本身。在这项研究中，开发了一种获得固有抗菌材料的新方法。通过中和羧基化的聚氨酯制备了含有 Ag(I)、Cu(II)、Zn(II)、Al(III) 和 Fe(III) 的聚合物阴离子聚合物。在 PEUA-Ag、PEUA-Fe 和 PEUA-Cu 离聚物的情况下，离子聚集体表现为增强填料颗粒，与原始羧基化聚合物相比，提高了系统的机械性能，提高了硬度和断裂强度。除了含铝聚合物外，所有其他实验的离聚物都表现出令人满意的抗菌性能。含银离子的聚合物具有最佳的抗菌效果，可抑制表皮葡萄球菌生长长达 16 天。环丙沙星也被吸附到上述离聚物上。抗生素和银离子对细菌生长抑制的协同作用至少持续 25 天。
