Departments of Genetics and Ophthalmology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Neurosci. 2010 Apr 7;30(14):4970-80. doi: 10.1523/JNEUROSCI.3456-09.2010.
Developing neural tissue undergoes a period of neurogenesis followed by a period of gliogenesis. The lineage relationships among glial cell types have not been defined for most areas of the nervous system. Here we use retroviruses to label clones of glial cells in the chick retina. We found that almost every clone had both astrocytes and oligodendrocytes. In addition, we discovered a novel glial cell type, with features intermediate between those of astrocytes and oligodendrocytes, which we have named the diacyte. Diacytes also share a progenitor cell with both astrocytes and oligodendrocytes.
发育中的神经组织经历一个神经发生期,随后是一个神经胶质发生期。大多数神经系统区域的神经胶质细胞类型之间的谱系关系尚未确定。在这里,我们使用逆转录病毒来标记鸡视网膜中的神经胶质细胞克隆。我们发现,几乎每个克隆都同时具有星形胶质细胞和少突胶质细胞。此外,我们还发现了一种新型的神经胶质细胞,其特征介于星形胶质细胞和少突胶质细胞之间,我们将其命名为双极细胞。双极细胞也与星形胶质细胞和少突胶质细胞共享一个祖细胞。