Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA.
J Cereb Blood Flow Metab. 2010 Jun;30(6):1100-4. doi: 10.1038/jcbfm.2010.46. Epub 2010 Apr 7.
In addition to the neuronal and behavioral consequences of excess glucocorticoid exposure, the cerebrovascular system can also be adversely affected by stressors. This study determined that chronic stress in adulthood decreased the vascular area fraction of the hippocampus and increased the vascular area fraction of the amygdala. In addition, the data indicated that prenatal exposure to synthetic glucocorticoids modulated the effects of adult stress on vascular area fraction of the hippocampus and amygdala. These data indicate that in addition to the well-documented stress-induced changes in neurons and glia, cerebral vasculature is also altered by exposure to stressors.
除了过量糖皮质激素暴露的神经元和行为后果外，脑血管系统也会受到应激源的不利影响。本研究确定，成年期的慢性应激会降低海马体的血管面积分数，并增加杏仁核的血管面积分数。此外，数据表明，产前暴露于合成糖皮质激素会调节成年期应激对海马体和杏仁核血管面积分数的影响。这些数据表明，除了众所周知的应激诱导的神经元和神经胶质变化外，脑血管系统也会因暴露于应激源而发生改变。
