Langford P, Williams A E, Kroll J S
University Department of Paediatrics, John Radcliffe Hospital, Oxford, U.K.
FEMS Microbiol Lett. 1991 Jan 15;61(2-3):347-50. doi: 10.1016/0378-1097(91)90578-x.
Pathogenic and non-pathogenic isolates of Streptococcus suis type 2 were screened to determine whether differences in superoxide dismutase (SOD) synthesis could explain the observed differences in their pathogenicity and intracellular fate in macrophages. A single band of SOD activity of similar Rf value was visualised in PAGE gels in all isolates and inhibition studies suggested that the cofactor present was manganese. There was no correlation between specific SOD activity and virulence. It is unlikely, therefore, that SOD produced by S. suis type 2 mediates intracellular survival of pathogenic isolates in macrophages.
对猪链球菌2型的致病性和非致病性分离株进行筛选，以确定超氧化物歧化酶（SOD）合成的差异是否可以解释观察到的它们在巨噬细胞中的致病性和细胞内存活情况的差异。在所有分离株的PAGE凝胶中都观察到一条具有相似Rf值的SOD活性条带，抑制研究表明存在的辅因子是锰。特定SOD活性与毒力之间没有相关性。因此，猪链球菌2型产生的SOD不太可能介导致病性分离株在巨噬细胞中的细胞内存活。
