人类1号染色体的CEPH联盟连锁图谱。

The CEPH consortium linkage map of human chromosome 1.

作者信息

Dracopoli N C, O'Connell P, Elsner T I, Lalouel J M, White R L, Buetow K H, Nishimura D Y, Murray J C, Helms C, Mishra S K

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

Genomics. 1991 Apr;9(4):686-700. doi: 10.1016/0888-7543(91)90362-i.

DOI:10.1016/0888-7543(91)90362-i

PMID:2037294

Abstract

This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 alpha-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals greater than 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM.

摘要

本文描述了人类1号染色体的人类多态性研究中心（CEPH）联合体连锁图谱。该图谱包含101个位点，这些位点由CEPH家族DNA产生的基因型定义，来自11个实验室的146种不同贡献。共有58个位点在图谱上被唯一定位，其似然支持率至少为1000:1。该图谱从两条染色体臂末端带中的位点（1p36.3中的位点D1Z2和1q44中的D1S68）延伸，并通过D1Z5α-卫星多态性在着丝粒处锚定。除单个位点外，其余位点以短间隔排列在固定图谱上，并标明了它们可能的位置。多点连锁分析提供的估计结果表明，男性、女性和性别平均图谱分别延伸308、478和390厘摩。性别平均图谱仅包含四个大于15厘摩的区间，58个唯一定位位点之间的平均遗传距离为6.7厘摩。