人类13号染色体的CEPH联盟连锁图谱。
The CEPH consortium linkage map of human chromosome 13.
作者信息
Bowcock A M, Gerken S C, Barnes R I, Shiang R, Jabs E W, Warren A C, Antonarakis S, Retief A E, Vergnaud G, Leppert M
机构信息
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
出版信息
Genomics. 1993 May;16(2):486-96. doi: 10.1006/geno.1993.1215.
The CEPH consortium map of chromosome 13 is presented. This map contains 59 loci defined by genotypes generated from CEPH family DNAs with 94 different probe and restriction enzyme combinations contributed by 9 laboratories. A total of 25 loci have been placed on the map with likelihood support of at least 1000:1. The map extends from loci in the centromeric region of chromosome 13 to the terminal band of the long arm. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 158, 203, and 178 cM respectively. The largest interval is 24 cM and is between D13Z1 (alpha RI) and ATP1AL1. The mean genetic distance between the 25 uniquely placed loci is 7 cM.
本文展示了13号染色体的CEPH联合体图谱。该图谱包含59个位点，这些位点由CEPH家族DNA的基因型定义，使用了9个实验室提供的94种不同的探针和限制酶组合。共有25个位点已定位在该图谱上，其似然支持率至少为1000:1。该图谱从13号染色体着丝粒区域的位点延伸至长臂的末端带。多点连锁分析估计，男性、女性和性别平均图谱分别延伸158、203和178厘摩。最大间隔为24厘摩，位于D13Z1（α RI）和ATP1AL1之间。25个唯一定位位点之间的平均遗传距离为7厘摩。
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