Department of Anatomy and Neurobiology, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
Int J Neurosci. 2010 Mar;120(3):192-200. doi: 10.3109/00207450903464579.
Neurogenesis in the hippocampus continues throughout adult life and can be regulated by the local microenvironment. To determine whether denervation stimulates neurogenesis in hippocampus, proliferation, migration, and differentiation of local neural stem cells (NSCs) in dentate gyrus was investigated after fimbria fornix transection. In the denervated hippocampus, NSCs proliferated markedly and migrated along the subgranular layer, and more newborn cells differentiated into neurons or astrocytes. After denervation, more newborn cells in the deafferented hippocampus expressed Brn-4 and differentiated into beta-Tubulin III positive neurons. It is concluded that the local NSCs in hippocampus may proliferate and migrate into granule cell layer, in which changes in the deafferented hippocampus provided a suitable microenvironment for hippocampal neurogenesis and the increased Brn-4 in denervated hippocampus may be involved in this process.
海马体中的神经发生在成年期仍持续进行，并可受到局部微环境的调控。为了确定去神经支配是否能刺激海马中的神经发生，我们研究了穹窿伞切断后齿状回局部神经干细胞（NSCs）的增殖、迁移和分化。在去神经支配的海马体中，NSCs 大量增殖并沿颗粒下层迁移，更多的新生细胞分化为神经元或星形胶质细胞。去神经支配后，去传入侧海马体中的更多新生细胞表达 Brn-4 并分化为β微管蛋白 III 阳性神经元。结论是，海马体中的局部 NSCs 可能增殖并迁移到颗粒细胞层，其中去传入侧海马体的变化为海马神经发生提供了一个合适的微环境，而去神经支配侧海马体中 Brn-4 的增加可能参与了这一过程。
