Department of Pharmacology and Toxicology, and Centre for Neuroscience Studies, Queens University, Kingston, ON, Canada.
Alcohol Clin Exp Res. 2010 Jun;34(6):1084-9. doi: 10.1111/j.1530-0277.2010.01184.x. Epub 2010 Apr 5.
Fetal alcohol spectrum disorder (FASD) is the umbrella term that describes the range of adverse developmental outcomes that may occur in the offspring of mothers who drink alcohol during pregnancy. FASD is associated with several comorbidities including epilepsy. The objective of the study was to evaluate the prevalence of epilepsy or a history of seizures in subjects with FASD and the contribution of relevant risk factors.
A retrospective chart review was conducted on all active charts (N = 1063) at two FASD clinics. After exclusion of subjects without a confirmed diagnosis, a total of 425 subjects between the ages of 2-49 were included in the analysis. The relationships between FASD diagnosis and other risk factors for co-occurrence of epilepsy or a seizure disorder (e.g., extent of exposure to alcohol and other drugs, type of birth, and trauma) were examined using chi-square and multivariate multinomial logistic regression.
Twenty-five (5.9%) individuals in the study population had a confirmed diagnosis of epilepsy, and 50 (11.8%) had at least one documented seizure episode, yielding an overall prevalence of 17.7% in this population. Importantly, a history of epilepsy or seizures was not different across the three diagnostic subgroups. In those subjects with available maternal drinking histories, first trimester exposure or drinking throughout all three trimesters were the predominant forms of fetal exposure. None of the other risk factors were associated with a greater prevalence of epilepsy or seizures.
There is a remarkably high prevalence of epilepsy/seizures in the FASD population.
胎儿酒精谱系障碍（FASD）是一个总称，用于描述母亲在怀孕期间饮酒可能导致的一系列不良发育后果。FASD 与多种合并症有关，包括癫痫。本研究的目的是评估 FASD 患者中癫痫或癫痫发作史的患病率，以及相关风险因素的作用。
对两家 FASD 诊所的所有活跃病历（N=1063）进行回顾性图表审查。排除无确诊诊断的患者后，共纳入 425 名年龄在 2-49 岁之间的患者进行分析。使用卡方检验和多变量多项逻辑回归检验 FASD 诊断与癫痫或癫痫发作障碍共病的其他风险因素（例如，酒精和其他药物暴露程度、分娩类型和创伤）之间的关系。
在研究人群中，有 25 人（5.9%）被确诊为癫痫，有 50 人（11.8%）至少有一次记录的癫痫发作，因此该人群的总患病率为 17.7%。重要的是，癫痫或癫痫发作史在三个诊断亚组之间没有差异。在有母亲饮酒史的患者中，前三个月暴露或整个三个孕期饮酒是胎儿暴露的主要形式。其他风险因素均与癫痫或癫痫发作的更高患病率无关。
FASD 人群中癫痫/癫痫发作的患病率非常高。
