棕色脂肪与饮食诱导产热的神话。
Brown fat and the myth of diet-induced thermogenesis.
机构信息
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
出版信息
Cell Metab. 2010 Apr 7;11(4):263-7. doi: 10.1016/j.cmet.2010.03.009.
Abstract
The notion that brown adipose tissue (BAT) in mice or humans maintains energy balance by burning off excess calories seems incompatible with evolutionary biology. Studies in obese rats and mice lacking UCP1 indicate that diet-induced thermogenesis by BAT is unlikely.
摘要
棕色脂肪组织（BAT）在小鼠或人类中通过燃烧多余的卡路里来维持能量平衡的观点似乎与进化生物学不符。在肥胖大鼠和缺乏 UCP1 的小鼠中的研究表明，BAT 引起的饮食诱导的产热不太可能。
相似文献
1
Brown fat and the myth of diet-induced thermogenesis.
Cell Metab. 2010 Apr 7;11(4):263-7. doi: 10.1016/j.cmet.2010.03.009.
2
Human brown adipose tissue.
Cell Metab. 2010 Apr 7;11(4):248-52. doi: 10.1016/j.cmet.2010.03.008.
3
Brown fat thermogenesis and body weight regulation in mice: relevance to humans.
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S23-7. doi: 10.1038/ijo.2010.179.
4
Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):403-8. doi: 10.1073/pnas.1017884108. Epub 2010 Dec 20.
5
Dietary factors evoke thermogenesis in adipose tissues.
Obes Res Clin Pract. 2014 Nov-Dec;8(6):e533-9. doi: 10.1016/j.orcp.2013.12.002. Epub 2014 Jan 18.
6
Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S7-16. doi: 10.1038/ijo.2010.177.
7
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.
Annu Rev Physiol. 2014;76:225-49. doi: 10.1146/annurev-physiol-021113-170252. Epub 2013 Nov 4.
8
Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet.
Eur J Nutr. 2014 Oct;53(7):1503-10. doi: 10.1007/s00394-014-0655-6. Epub 2014 Jan 28.
9
Absence of adaptive nonshivering thermogenesis in a marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata).
J Comp Physiol B. 2012 Apr;182(3):393-401. doi: 10.1007/s00360-011-0623-x. Epub 2011 Oct 16.
10
Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
Endocrinology. 2010 Jan;151(1):432-40. doi: 10.1210/en.2009-0667. Epub 2009 Nov 11.
引用本文的文献
1
Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss.
Metabolism. 2025 Feb;163:156100. doi: 10.1016/j.metabol.2024.156100. Epub 2024 Dec 12.
2
Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury.
Sci Rep. 2024 Aug 7;14(1):18292. doi: 10.1038/s41598-024-69356-w.
3
Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity.
Physiol Res. 2024 Aug 30;73(S1):S279-S294. doi: 10.33549/physiolres.935361. Epub 2024 May 15.
4
Brown adipose tissue: can it keep us slim? A discussion of the evidence for and against the existence of diet-induced thermogenesis in mice and men.
Philos Trans R Soc Lond B Biol Sci. 2023 Oct 23;378(1888):20220220. doi: 10.1098/rstb.2022.0220. Epub 2023 Sep 4.
5
Brown Adipose Tissue: Activation and Metabolism in Humans.
Endocrinol Metab (Seoul). 2023 Apr;38(2):214-222. doi: 10.3803/EnM.2023.1659. Epub 2023 Mar 27.
6
Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies.
Antioxidants (Basel). 2023 Jan 14;12(1):196. doi: 10.3390/antiox12010196.
7
The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases.
Int J Mol Sci. 2022 Aug 21;23(16):9448. doi: 10.3390/ijms23169448.
8
Could the ketogenic diet induce a shift in thyroid function and support a metabolic advantage in healthy participants? A pilot randomized-controlled-crossover trial.
PLoS One. 2022 Jun 3;17(6):e0269440. doi: 10.1371/journal.pone.0269440. eCollection 2022.
9
Brown Adipose Tissue-A Translational Perspective.
Endocr Rev. 2023 Mar 4;44(2):143-192. doi: 10.1210/endrev/bnac015.
10
Diverse and Complementary Effects of Ghrelin and Obestatin.
Biomolecules. 2022 Mar 29;12(4):517. doi: 10.3390/biom12040517.
本文引用的文献
1
A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes.
Diabetes. 2010 Feb;59(2):323-9. doi: 10.2337/db09-1471.
2
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.
Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014.
3
Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity.
J Biol Chem. 2008 Oct 10;283(41):27688-27697. doi: 10.1074/jbc.M804268200. Epub 2008 Aug 4.
4
Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance.
FASEB J. 2008 Nov;22(11):3925-37. doi: 10.1096/fj.08-108266. Epub 2008 Jul 21.
5
Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.
J Lipid Res. 2007 Jan;48(1):41-51. doi: 10.1194/jlr.M600287-JLR200. Epub 2006 Oct 14.
6
Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress.
Endocrinology. 2006 May;147(5):2468-80. doi: 10.1210/en.2005-1216. Epub 2006 Feb 9.
7
Norepinephrine- and epinephrine-deficient mice gain weight normally on a high-fat diet.
Obes Res. 2005 Sep;13(9):1518-22. doi: 10.1038/oby.2005.185.
8
UCP1 deficiency increases susceptibility to diet-induced obesity with age.
Aging Cell. 2005 Jun;4(3):147-55. doi: 10.1111/j.1474-9726.2005.00157.x.
9
Low physical activity levels of modern Homo sapiens among free-ranging mammals.
Int J Obes (Lond). 2005 Jan;29(1):151-6. doi: 10.1038/sj.ijo.0802842.
10
Energy intake/physical activity interactions in the homeostasis of body weight regulation.
Nutr Rev. 2004 Jul;62(7 Pt 2):S98-104. doi: 10.1111/j.1753-4887.2004.tb00095.x.
Zotero 插件