Andrade João Marcus Oliveira, Frade Alessandra Caroline Montes, Guimarães Juliana Bohnen, Freitas Kátia Michelle, Lopes Miriam Teresa Paz, Guimarães André Luiz Sena, de Paula Alfredo Maurício Batista, Coimbra Cândido Celso, Santos Sérgio Henrique Sousa
Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil.
Eur J Nutr. 2014 Oct;53(7):1503-10. doi: 10.1007/s00394-014-0655-6. Epub 2014 Jan 28.
Adipose tissue is central to the regulation of energy balance. Two functionally different fat pads are present in mammals: white adipose tissue, the primary site of triglyceride storage, and brown adipose tissue (BAT), which is specialized in heat production. In this context, new strategies capable of modulating the development and function of white and BAT become relevant. In the present study, we analyzed the influence of resveratrol (sirtuin activator) on energy balance and the expression of thermogenesis markers.
Mice were divided into two groups: standard diet (ST) and standard diet plus resveratrol (ST + RSV).
After 2 months of treatment, ST + RSV mice presented significantly decreased fat accumulation in adipose tissue, with diminished total cholesterol and glucose plasma levels. Additionally, increased oxygen consumption was observed in ST + RSV group. Analyses of mRNA of thermogenesis-related genes showed significant increase in UCP1, SIRT1, PTEN and BMP-7 expression in BAT.
Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1 and SIRT1, which can mediate higher energy expenditure and decreased fat accumulation in adipose tissue.
脂肪组织是能量平衡调节的核心。哺乳动物体内存在两种功能不同的脂肪垫：白色脂肪组织，即甘油三酯储存的主要部位，以及专门用于产热的棕色脂肪组织（BAT）。在此背景下，能够调节白色脂肪组织和棕色脂肪组织发育及功能的新策略变得至关重要。在本研究中，我们分析了白藜芦醇（一种沉默调节蛋白激活剂）对能量平衡及产热标志物表达的影响。
将小鼠分为两组：标准饮食组（ST）和标准饮食加白藜芦醇组（ST + RSV）。
经过2个月的治疗，ST + RSV组小鼠脂肪组织中的脂肪堆积显著减少，血浆总胆固醇和葡萄糖水平降低。此外，ST + RSV组的耗氧量增加。对产热相关基因的mRNA分析显示，BAT中UCP1、SIRT1、PTEN和BMP - 7的表达显著增加。
我们的数据表明，口服白藜芦醇所产生的代谢改善至少部分与产热增加有关，随后UCP1和SIRT1高表达，这可介导更高的能量消耗并减少脂肪组织中的脂肪堆积。
