Sakamoto Tomoya, Takahashi Nobuyuki, Goto Tsuyoshi, Kawada Teruo
Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Japan.
Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Japan; Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan.
Obes Res Clin Pract. 2014 Nov-Dec;8(6):e533-9. doi: 10.1016/j.orcp.2013.12.002. Epub 2014 Jan 18.
In dietary factors, energetic food constituents and the "non-energetic food constituents" such as smell and taste through sensory nerve stimulation have been found to be linked intrinsically with the accelerated expression of diet-induced thermogenesis that accompanies the burning of fat within brown adipose tissues (BAT). The compounds are responsible for BAT and uncoupling protein-1 (UCP1) activation or induction caused by food components. Many of these activate and strengthen BAT activation through the following pathway: sensory stimulations induce sympathetic nerve activation through central phase. In the fight against obesity, the development of food compounds and pharmaceuticals that activate or induce BAT and UCP1 is expected. In this review, we discuss that how dietary compounds effect thermogenesis through BAT and UCP1.
在饮食因素中,高热量食物成分以及通过感觉神经刺激产生气味和味道等“非热量食物成分”,已被发现与棕色脂肪组织(BAT)内脂肪燃烧时饮食诱导产热的加速表达存在内在联系。这些化合物负责由食物成分引起的BAT和解偶联蛋白-1(UCP1)的激活或诱导。其中许多化合物通过以下途径激活并增强BAT的活性:感觉刺激通过中枢阶段诱导交感神经激活。在对抗肥胖的过程中,有望开发出能够激活或诱导BAT和UCP1的食物化合物和药物。在本综述中,我们讨论了饮食化合物如何通过BAT和UCP1影响产热。