Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
J Clin Endocrinol Metab. 2010 Jun;95(6):2957-62. doi: 10.1210/jc.2009-2496. Epub 2010 Apr 7.
Changes in appetite-regulating peptides may impact food intake during puberty and facilitate the pubertal growth spurt. Peptide YY (PYY) is an anorexigenic hormone that is high in anorexia nervosa and low in obesity, inhibits GnRH secretion, and is suppressed by GH administration. The relationship between PYY and GH has not been examined across puberty.
We hypothesized that PYY would be inversely associated with GH in adolescents and would be lowest when GH is highest.
We conducted a cross-sectional study at a Clinical Research Center.
We studied 87 children, 46 boys and 41 girls ages 9-17 yr at Tanner stages 1-5 of puberty (10th-90th percentiles for body mass index).
We measured fasting PYY and nadir GH levels after administration of an oral glucose load. Leptin levels were also measured.
Fasting PYY was lowest and nadir GH highest in boys in Tanner stages 3-4 (P = 0.02) and in girls in Tanner stages 2-3 (P = 0.02). Leptin levels were highest in early pubertal boys and late pubertal girls. For the group as a whole and within genders, even after controlling for body mass index, log nadir GH correlated inversely with log PYY (P = 0.003, 0.07, and 0.02). PYY levels did not correlate with leptin levels.
During mid-puberty, at a time when GH levels are the highest, PYY is at a nadir, and these low PYY levels may facilitate pubertal progression and growth.
食欲调节肽的变化可能会影响青春期的食物摄入，并促进青春期生长突增。肽 YY（PYY）是一种厌食激素，在神经性厌食症中含量高，在肥胖症中含量低，抑制 GnRH 分泌，并被 GH 给药抑制。PYY 和 GH 之间的关系尚未在整个青春期进行过检查。
我们假设 PYY 在青少年中与 GH 呈负相关，并且在 GH 最高时最低。
我们在临床研究中心进行了一项横断面研究。
我们研究了 87 名儿童，46 名男孩和 41 名女孩，年龄在 9-17 岁，青春期分期为 1-5 期（身高体重指数的第 10-90 百分位）。
我们在口服葡萄糖负荷后测量空腹 PYY 和 GH 最低值。还测量了瘦素水平。
在青春期分期 3-4 期的男孩（P = 0.02）和青春期分期 2-3 期的女孩（P = 0.02）中，空腹 PYY 最低，GH 最低值最高。瘦素水平在早期青春期男孩和晚期青春期女孩中最高。对于整个组和性别内，即使在控制体重指数后，log 最低 GH 与 log PYY 呈负相关（P = 0.003、0.07 和 0.02）。PYY 水平与瘦素水平无关。
在青春期中期，当 GH 水平最高时，PYY 处于最低点，这些低 PYY 水平可能促进青春期进展和生长。
