Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.
J Innate Immun. 2009;1(5):413-20. doi: 10.1159/000226256. Epub 2009 Jun 24.
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the defensin, virus and target cell. Regulation of viral infection by defensins is achieved by multiple mechanisms. This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections.
防御素是先天宿主防御中重要的抗微生物肽。除了直接的抗菌作用外,防御素还调节免疫反应。越来越多的证据表明,防御素通过正向或负向调节包膜和非包膜病毒的感染,表现出复杂的功能。防御素对病毒感染的影响似乎因防御素、病毒和靶细胞的不同而具有特异性。防御素对病毒感染的调节是通过多种机制实现的。本文综述了防御素与病毒感染之间的相互作用、防御素的作用机制以及防御素在病毒感染中的体内研究。