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Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus.措施与对策：I 型干扰素（IFN-α/β）对西尼罗河病毒的抗病毒反应。
J Innate Immun. 2009;1(5):435-45. doi: 10.1159/000226248. Epub 2009 Jun 24.
2
Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival.α/β干扰素通过限制细胞嗜性和增强神经元存活来预防西尼罗河病毒致死性感染。
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Splenic macrophages are required for protective innate immunity against West Nile virus.脾脏巨噬细胞是抵抗西尼罗河病毒的保护性固有免疫所必需的。
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本文引用的文献

1
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.Toll样受体7通过白细胞介素23依赖的免疫细胞浸润和归巢减轻致死性西尼罗河脑炎。
Immunity. 2009 Feb 20;30(2):242-53. doi: 10.1016/j.immuni.2008.11.012. Epub 2009 Feb 5.
2
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.在经干扰素-β 预刺激后，Toll样受体4（TLR4）配体可诱导小鼠传统树突状细胞和人单核细胞产生干扰素-α。
J Immunol. 2009 Jan 15;182(2):820-8. doi: 10.4049/jimmunol.182.2.820.
3
RNA recognition and signal transduction by RIG-I-like receptors.维甲酸诱导基因I样受体介导的RNA识别与信号转导
Immunol Rev. 2009 Jan;227(1):54-65. doi: 10.1111/j.1600-065X.2008.00727.x.
4
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.胞质病毒传感器视黄酸诱导基因I（RIG-I）是一种依赖于5'-三磷酸的双链RNA转位酶。
Science. 2009 Feb 20;323(5917):1070-4. doi: 10.1126/science.1168352. Epub 2009 Jan 1.
5
Toll-like receptor 3 has a protective role against West Nile virus infection.Toll样受体3对西尼罗河病毒感染具有保护作用。
J Virol. 2008 Nov;82(21):10349-58. doi: 10.1128/JVI.00935-08. Epub 2008 Aug 20.
6
Pathogen recognition by innate receptors.天然受体对病原体的识别。
J Infect Chemother. 2008 Apr;14(2):86-92. doi: 10.1007/s10156-008-0596-1. Epub 2008 Apr 30.
7
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.抗病毒免疫中RIG-I样受体对双链RNA的差异性识别
J Exp Med. 2008 Jul 7;205(7):1523-7. doi: 10.1084/jem.20081210.
8
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.视黄酸诱导基因-I和黑色素瘤分化相关基因5对双链核糖核酸的长度依赖性识别
J Exp Med. 2008 Jul 7;205(7):1601-10. doi: 10.1084/jem.20080091.
9
Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.干扰素调节因子IRF-7诱导抗病毒α干扰素反应并抵御西尼罗河病毒致死性感染。
J Virol. 2008 Sep;82(17):8465-75. doi: 10.1128/JVI.00918-08. Epub 2008 Jun 18.
10
West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction.西尼罗河病毒非结构蛋白1抑制Toll样受体3信号转导。
J Virol. 2008 Sep;82(17):8262-71. doi: 10.1128/JVI.00226-08. Epub 2008 Jun 18.

措施与对策：I 型干扰素（IFN-α/β）对西尼罗河病毒的抗病毒反应。

Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus.

机构信息

Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

出版信息

J Innate Immun. 2009;1(5):435-45. doi: 10.1159/000226248. Epub 2009 Jun 24.

DOI:10.1159/000226248
PMID:20375601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2920482/
Abstract

As a first line of defense after viral infection, host cells develop an intrinsic immune response to control virus dissemination and protect against serious infection. Recent experiments have shown a dominant role of the IFN-alpha/beta response in protection against lethal West Nile virus (WNV) by limiting the cellular and tissue tropism of infection. This review will focus on advances in identifying the host sensors that detect WNV and the adaptor molecules and signaling pathways that regulate the induction of IFN-alpha/beta defenses that limit WNV replication, spread and pathogenesis.

摘要

作为病毒感染后的第一道防线，宿主细胞会产生固有免疫反应来控制病毒传播并防止严重感染。最近的实验表明，IFN-α/β反应在限制西尼罗河病毒（WNV）的细胞和组织嗜性方面发挥了主导作用，从而对保护机体免受致命性WNV 感染具有重要作用。本综述将重点介绍鉴定宿主传感器以识别 WNV 的研究进展，以及调节 IFN-α/β防御反应诱导的衔接分子和信号通路，这些反应可以限制 WNV 的复制、传播和发病机制。