措施与对策：I 型干扰素（IFN-α/β）对西尼罗河病毒的抗病毒反应。
Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus.
机构信息
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
J Innate Immun. 2009;1(5):435-45. doi: 10.1159/000226248. Epub 2009 Jun 24.
Abstract
As a first line of defense after viral infection, host cells develop an intrinsic immune response to control virus dissemination and protect against serious infection. Recent experiments have shown a dominant role of the IFN-alpha/beta response in protection against lethal West Nile virus (WNV) by limiting the cellular and tissue tropism of infection. This review will focus on advances in identifying the host sensors that detect WNV and the adaptor molecules and signaling pathways that regulate the induction of IFN-alpha/beta defenses that limit WNV replication, spread and pathogenesis.
摘要
作为病毒感染后的第一道防线，宿主细胞会产生固有免疫反应来控制病毒传播并防止严重感染。最近的实验表明，IFN-α/β反应在限制西尼罗河病毒（WNV）的细胞和组织嗜性方面发挥了主导作用，从而对保护机体免受致命性WNV 感染具有重要作用。本综述将重点介绍鉴定宿主传感器以识别 WNV 的研究进展，以及调节 IFN-α/β防御反应诱导的衔接分子和信号通路，这些反应可以限制 WNV 的复制、传播和发病机制。
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