Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Int J Gynecol Cancer. 2010 Apr;20(3):398-403. doi: 10.1111/IGC.0b013e3181d02ff2.
To examine the effects of dietary supplements on high-risk human papillomavirus (HPV) infection and cervical carcinogenesis.
A multi-institutional cross-sectional study was carried out to examine whether dietary supplements were associated with the risk of cervical intraepithelial neoplasia (CIN). We enrolled 1096 women aged 18 to 65 years to participate in an HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls; 90 CIN I and 72 CIN II/III). The details of each participant's routine dietary intake during the prior year were collected. Specific dietary supplements were classified into 5 categories, namely, multivitamins, multinutrients, vitamin C, calcium, and miscellaneous.
A higher HPV viral load was associated with an increased risk of CIN II/III (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.54-7.16; P for trend 0.002). Dietary supplement use including multivitamins (OR, 0.21; 95% CI, 0.09-0.48), vitamins A (OR, 0.19; 95% CI, 0.07-0.53), C (OR, 0.24; 95% CI, 0.10-0.56), E (OR, 0.20; 95% CI, 0.07-0.53), and calcium (OR, 0.21; 95% CI, 0.08-0.50) was significantly associated with a lower risk of CIN II/III. The patients who took multivitamins and had a lower HPV viral load (<15.5 relative light units/positive control) had a significantly decreased frequency of CIN I (OR, 0.35; 95% CI, 0.14-0.87; interaction P = 0.925) and CIN II/III (OR, 0.11; 95% CI, 0.04-0.37; interaction P = 0.304).
The findings of this study suggest that dietary supplements may reduce the risk of CINs in women with high-risk HPV infection.
研究膳食补充剂对高危型人乳头瘤病毒（HPV）感染和宫颈癌发生的影响。
进行了一项多机构的横断面研究，以研究膳食补充剂是否与宫颈上皮内瘤变（CIN）的风险相关。我们招募了 1096 名年龄在 18 至 65 岁之间的女性参加一项 HPV 队列研究，该研究从 2006 年 3 月持续至今。在本分析中，我们纳入了 328 名 HPV 阳性妇女（166 名对照；90 名 CIN I 和 72 名 CIN II/III）。收集了每位参与者在过去一年中常规饮食摄入的详细信息。将特定的膳食补充剂分为 5 类，即多种维生素、多种营养素、维生素 C、钙和其他。
较高的 HPV 病毒载量与 CIN II/III 的风险增加相关（比值比 [OR]，3.32；95%置信区间 [CI]，1.54-7.16；趋势 P 值<0.002）。包括多种维生素（OR，0.21；95%CI，0.09-0.48）、维生素 A（OR，0.19；95%CI，0.07-0.53）、维生素 C（OR，0.24；95%CI，0.10-0.56）、维生素 E（OR，0.20；95%CI，0.07-0.53）和钙（OR，0.21；95%CI，0.08-0.50）的膳食补充剂使用与 CIN II/III 的风险降低显著相关。服用多种维生素且 HPV 病毒载量较低（<15.5 相对光单位/阳性对照）的患者 CIN I（OR，0.35；95%CI，0.14-0.87；交互 P = 0.925）和 CIN II/III（OR，0.11；95%CI，0.04-0.37；交互 P = 0.304）的发生率显著降低。
本研究结果表明，膳食补充剂可能降低高危 HPV 感染女性的 CIN 风险。
