Ferrari Filippo Alberto, Magni Francesca, Bosco Mariachiara, Biancotto Giulia, Zorzato Pier Carlo, Laganà Antonio Simone, Chiantera Vito, Raffaelli Ricciarda, Franchi Massimo, Uccella Stefano, Garzon Simone
Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, Italy.
Unit of Gynecologic Oncology, ARNAS "Civico-Di Cristina-Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
Healthcare (Basel). 2023 Jun 5;11(11):1652. doi: 10.3390/healthcare11111652.
There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice.
有证据表明，饮食和营养是几种癌症的可改变风险因素。近年来，妇科领域对微量营养素的关注有所增加，尤其是关于人乳头瘤病毒（HPV）感染方面。我们对截至2022年12月的文献进行了综述，旨在阐明微量营养素、矿物质和维生素对HPV感染史及宫颈癌发展的影响。我们纳入了以评估膳食补充剂为主要目的的研究，特别是钙、锌、铁、硒、类胡萝卜素以及维生素A、B12、C、D、E和K。不同的微量元素和微量营养素通过干预HPV感染自然史、宫颈发育异常发展和浸润性疾病的不同阶段，显示出对宫颈癌的潜在保护作用。医疗保健提供者应了解并将文献证据纳入咨询过程，尽管现有研究提供的证据质量较低，仍建议进一步开展精心设计的调查，以便为临床实践提供明确指导。
