Hypertension and Renal Center of Excellence, Department of Medicine, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA.
J Hypertens. 2010 Jul;28(7):1422-8. doi: 10.1097/HJH.0b013e3283392673.
The Bogalusa Heart Study is a long-term study on cardiovascular disease and has followed a biracial (black/white) population from childhood. Risk factor data pertaining to many patients have been collected over 35 years, and the time course of hypertension has been documented by repeated examinations and measurements. Considerable sex and racial differences have been found to be related to cardiovascular disease. Urinary angiotensinogen (UAGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension and kidney disease. We aimed to determine the relationship of UAGT with traditional cardiovascular disease risk factors in asymptomatic young adults in this biracial population.
We recruited 251 individuals and collected a single random spot urine sample from each one. Because UAGT is significantly increased in diabetic patients and the use of antihypertensive drugs affects UAGT levels, we excluded patients who had diabetes, who were receiving antihypertensive treatment, or both. Consequently, 190 participants were included for this analysis.
UAGT levels did not differ with race or sex, but were significantly correlated with SBP (r = +0.23, P = 0.0015) and DBP (r = +0.24, P = 0.0012). Moreover, high correlations were shown in men, especially in black men (SBP, r = +0.85, P = 0.0005 and DBP, r = +0.72, P = 0.0079). Thus, UAGT is correlated with blood pressure in men, even when they do not show overt proteinuria or albuminuria.
The biomarker, UAGT, may facilitate the identification of individuals that are at increased risk for the development of hypertension and early asymptomatic renal disease.
博加拉卢萨心脏研究是一项针对心血管疾病的长期研究，其研究对象为一个跨种族（黑/白）的人群，从儿童时期开始进行跟踪调查。35 年来，研究人员收集了与许多患者相关的风险因素数据，并通过多次检查和测量记录了高血压的时间进程。研究发现，心血管疾病与性别和种族差异有很大关系。尿血管紧张素原（UAGT）是高血压和肾脏疾病中肾素-血管紧张素系统内在活性的新型生物标志物。我们旨在确定 UAGT 与该跨种族人群中无症状年轻成年人的传统心血管疾病风险因素之间的关系。
我们招募了 251 名个体，并从每个人身上采集了一份随机尿液样本。由于 UAGT 在糖尿病患者中显著增加，且使用降压药物会影响 UAGT 水平，因此我们排除了患有糖尿病、正在接受降压治疗或两者兼有的患者。因此，有 190 名参与者纳入了本分析。
UAGT 水平与种族或性别无关，但与 SBP（r = +0.23，P = 0.0015）和 DBP（r = +0.24，P = 0.0012）显著相关。此外，在男性中表现出更高的相关性，尤其是在黑人男性中（SBP，r = +0.85，P = 0.0005 和 DBP，r = +0.72，P = 0.0079）。因此，即使男性没有明显的蛋白尿或白蛋白尿，UAGT 也与血压相关。
生物标志物 UAGT 可能有助于识别发生高血压和早期无症状肾脏疾病风险增加的个体。
