毛稔叶的止泻活性
Antidiarrhoeal Activity of Leaves of Melastoma malabathricum Linn.
作者信息
Sunilson J A J, Anandarajagopal K, Kumari A V A G, Mohan S
机构信息
School of Pharmacy, Masterskill University College Health Sciences, G-8, Jalan Kemacahaya 11, Taman Kemacahaya, Batu-9, Cheras 43200, Selangor, Malaysia.
出版信息
Indian J Pharm Sci. 2009 Nov;71(6):691-5. doi: 10.4103/0250-474X.59556.
Abstract
The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.
摘要
通过在瑞士小鼠中采用四种腹泻实验模型，研究了野牡丹科植物地稔叶水提取物的止泻作用。地稔水提取物处理的小鼠粪便排出量显著减少，并保护它们免受蓖麻油诱导的腹泻。该提取物还减少了硫酸镁诱导的肠液分泌以及小鼠给予炭末后胃肠道的蠕动。给予高达2000mg/kg剂量的受试提取物后，未观察到小鼠死亡和明显的全身虚弱迹象。
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