自然尖峰序列在啮齿动物海马苔藓纤维突触引发短时间和长时间的动力学变化。
Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents.
机构信息
Neuroscience Research Center of the Charité, Universitätsmedizin Berlin, Berlin, Germany.
出版信息
PLoS One. 2010 Apr 1;5(4):e9961. doi: 10.1371/journal.pone.0009961.
Abstract
BACKGROUND
Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.
METHODOLOGY/PRINCIPAL FINDINGS: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.
CONCLUSIONS/SIGNIFICANCE: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.
摘要
背景
在广泛的时间尺度上，从毫秒到小时，突触表现出显著不同形式的可塑性。突触可塑性的研究通常使用固定频率的刺激来激活突触，而神经元的体内活动是不规则的。
方法/主要发现：本文使用细胞外和全细胞电生理记录，研究了体外海马苔藓纤维突触对从行为啮齿动物齿状回颗粒细胞位置细胞放电的体内记录获得的刺激模式的突触反应。我们发现，在呈现自然刺激序列时，突触强度在短时间和长时间尺度上都受到强烈调节。
结论/意义：我们得出结论，海马苔藓纤维突触的动态短期和长期突触可塑性在正常突触功能中起着重要作用。
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