Department of Anatomy, Kansai University of Health Sciences, Osaka, Japan.
Histol Histopathol. 2010 Jun;25(6):781-94. doi: 10.14670/HH-25.781.
Lymphocyte trafficking into lymph nodes and Peyer's patches is mediated primarily by specifically differentiated venules, called high endothelial venules (HEVs), located in the tissue parenchyma. HEVs have a unique morphology and phenotype, which enables them to interact with circulating lymphocytes efficiently. That is, the HEV endothelial cells have a tall and plump appearance, and constitutively express multiple adhesion molecules and chemokines on their surface. These molecules can interact with cognate receptors on circulating lymphocytes, thereby mediating the stepwise and sequential lymphocyte adhesion and transendothelial migration (TEM) at the HEV endothelial luminal surface. This review summarizes the fine morphological aspects of the unique HEV endothelial cells, with special reference to the spatial distribution of the adhesion molecules and chemokines that regulate lymphocyte migration.
淋巴细胞向淋巴结和派尔氏斑的归巢主要由特定分化的小静脉介导，这些小静脉称为高内皮小静脉（HEV），位于组织实质中。HEV 具有独特的形态和表型，使其能够有效地与循环淋巴细胞相互作用。也就是说，HEV 内皮细胞外观高大饱满，表面持续表达多种黏附分子和趋化因子。这些分子可以与循环淋巴细胞上的同源受体相互作用，从而介导淋巴细胞在 HEV 内皮管腔表面的逐步和连续的黏附和穿越内皮迁移（TEM）。本文综述了独特的 HEV 内皮细胞的精细形态学方面，特别参考了调节淋巴细胞迁移的黏附分子和趋化因子的空间分布。
