[ALOX5AP基因SG13S114 A/T多态性与动脉粥样硬化的关联]
[Association of the ALOX5AP gene SG13S114 A/T polymorphism with atherosclerosis].
作者信息
He Ying-lei, Jin Xiao-ping, Zhu Min, Lin Xian-fang, Xie Zong-lin, Chen Qiu-yue
机构信息
Department of Neurology, Taizhou Hospital, Taizhou, Zhejiang, P.R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Apr;27(2):186-9. doi: 10.3760/cma.j.issn.1003-9406.2010.02.015.
OBJECTIVE
To investigate the relationship between the polymorphism of SG13S114 A/T in the 5-lipoxygenase-activating protein (ALOX5AP) gene and the stability of carotid atherosclerosis.
METHODS
Polymorphism of SG13S114 A/T in the ALOX5AP gene was analyzed in 152 cases of acute infarction with stable plaque, and 132 cases of acute infarction with vulnerable plaques, by using polymerase chain reaction and restriction fragment length polymorphism. Carotid artery plaque was analyzed by carotid artery color ultrasound.
RESULTS
The frequencies of SG13S114 AA genotype and the A allele in the vulnerable plaque group were higher than that in the stable plaque group (P< 0.01).
CONCLUSION
The polymorphism of SG13S114 A/T in the ALOX5AP gene may be associated with the instability of atherosclerosis. And the SG13S114 A allele may be a risk factor of vulnerable plaques.
目的
探讨5-脂氧合酶激活蛋白（ALOX5AP）基因中SG13S114 A/T多态性与颈动脉粥样硬化稳定性之间的关系。
方法
采用聚合酶链反应和限制性片段长度多态性分析方法，对152例有稳定斑块的急性梗死患者和132例有易损斑块的急性梗死患者的ALOX5AP基因中SG13S114 A/T多态性进行分析。通过颈动脉彩色超声分析颈动脉斑块情况。
结果
易损斑块组中SG13S114 AA基因型和A等位基因的频率高于稳定斑块组（P<0.01）。
结论
ALOX5AP基因中SG13S114 A/T多态性可能与动脉粥样硬化的不稳定性有关。且SG13S114 A等位基因可能是易损斑块的一个危险因素。
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