McRorie J, Krier J, Adams T
Department of Physiology, Michigan State University, East Lansing 48824-1101.
J Auton Nerv Syst. 1991 Mar;32(3):205-15. doi: 10.1016/0165-1838(91)90115-j.
Regulation of colon function depends on the location of nerve cell bodies and the distribution of intrinsic nerve fibers in the myenteric plexus. The morphology and projections of myenteric neurons through colonic fiber bundles in cat colon were determined using in vivo retrograde transport of HRP and Fast blue. Myenteric neurons were found to project from at least 5 to 59 mm orad (mean: 42 mm) or aborad (mean: 54 mm) through colonic fiber bundles. Approximately 73% of labelled cells were in ganglia within 2.8 mm of colonic fiber bundles in the axis of circular muscle fibers; none was beyond 7.7 mm. There were 2 soma morphologies. One type (Dogiel type I) had a mean soma diameter of 40.5 microns and had a rough somal surface. There were few if any short, broad dendrites, but its one long process extended to a branch point of an adjacent colonic fiber bundle. The other type (Dogiel type III) had a mean soma diameter of 26.4 microns, had a smooth somal surface and had few if any fine dendrites. It also projected a single long axon to colonic fiber bundles. There were twice as many Dogiel type III neurons. We conclude that myenteric neurons in the cat colon project both orad and aborad over relatively long distances through colonic fiber bundles where they form another intrinsic neuronal connection for the myenteric plexus.
结肠功能的调节取决于神经细胞体的位置以及肌间神经丛中内在神经纤维的分布。利用HRP和固蓝的体内逆行运输法，确定了猫结肠中肌间神经元通过结肠纤维束的形态和投射。发现肌间神经元通过结肠纤维束向口腔方向至少投射5至59毫米（平均：42毫米）或向肛门方向投射（平均：54毫米）。约73%的标记细胞位于环形肌纤维轴上结肠纤维束2.8毫米范围内的神经节中；无一超过7.7毫米。有两种胞体形态。一种类型（多吉尔I型）的胞体平均直径为40.5微米，胞体表面粗糙。几乎没有短而宽的树突，但它的一个长突起延伸至相邻结肠纤维束的一个分支点。另一种类型（多吉尔III型）的胞体平均直径为26.4微米，胞体表面光滑，几乎没有细树突。它也向结肠纤维束投射一条单一的长轴突。多吉尔III型神经元的数量是前者的两倍。我们得出结论，猫结肠中的肌间神经元通过结肠纤维束向口腔和肛门方向进行相对远距离的投射，在那里它们为肌间神经丛形成了另一种内在神经元连接。
