Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Int J Mol Sci. 2022 Jul 23;23(15):8128. doi: 10.3390/ijms23158128.
Chronic obstructive pulmonary disease (COPD) is a widespread disease associated with high rates of disability and mortality. COPD is characterized by chronic inflammation in the bronchi as well as systemic inflammation, which contributes significantly to the clinically heterogeneous course of the disease. Lipid metabolism disorders are common in COPD, being a part of its pathogenesis. High-density lipoproteins (HDLs) are not only involved in lipid metabolism, but are also part of the organism's immune and antioxidant defense. In addition, HDL is a versatile transport system for endogenous regulatory agents and is also involved in the removal of exogenous substances such as lipopolysaccharide. These functions, as well as information about lipoprotein metabolism disorders in COPD, allow a broader assessment of their role in the pathogenesis of heterogeneous and comorbid course of the disease.
慢性阻塞性肺疾病（COPD）是一种广泛存在的疾病，与高残疾率和高死亡率相关。COPD 的特征是支气管慢性炎症和全身炎症，这对疾病的临床异质性过程有重要贡献。脂代谢紊乱在 COPD 中很常见，是其发病机制的一部分。高密度脂蛋白（HDL）不仅参与脂质代谢，还是机体免疫和抗氧化防御的一部分。此外，HDL 是内源性调节因子的多功能转运系统，也参与外源性物质如脂多糖的清除。这些功能以及关于 COPD 中脂蛋白代谢紊乱的信息，使得我们能够更全面地评估它们在疾病异质性和合并症发病机制中的作用。
