凝集素共轭壳聚糖荧光纳米颗粒的制备与表征

Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles.

作者信息

Liu Jingping, Zhang Lanlan, Wang Chen, Xu Hongyan, Zhao Xiaojun

机构信息

Nanomedicine Laboratory, Center for Regenerative Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.

出版信息

Mol Biosyst. 2010 Jun;6(6):954-7. doi: 10.1039/b927040j.

DOI:10.1039/b927040j

PMID:20379582

Abstract

The purpose of this study was to design and evaluate a novel target nanoparticle for disease detection and drug delivery using the biotin-avidin binding system. The formed lectin-conjugated chitosan fluorescent nanoparticles were of spherical shape(100-200 nm in diameter), which were more stable under light than pure fluorescein isothiocyanate (FITC).

摘要

本研究的目的是设计并评估一种利用生物素-抗生物素蛋白结合系统用于疾病检测和药物递送的新型靶向纳米颗粒。所形成的凝集素共轭壳聚糖荧光纳米颗粒呈球形（直径为100 - 200纳米），在光照下比纯异硫氰酸荧光素（FITC）更稳定。