Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
Pediatr Nephrol. 2010 Dec;25(12):2401-12. doi: 10.1007/s00467-010-1508-z. Epub 2010 Apr 9.
The incidence of pediatric acute kidney injury (AKI) is increasing. AKI has been found to be independently associated with increased mortality, and current management options are limited in that they are mainly supportive. The use of various definitions of AKI can still be found in the literature, making it difficult to discern the epidemiology behind pediatric AKI. The use of a more uniform definition is a necessary first step to clarify AKI epidemiology and direct our research efforts, and it will ultimately improve prognosis. There is evidence that neonates and infants may be at higher risk for AKI than adults. However, the least amount of research is found for this youngest age group, and more focused efforts on this population are necessary. This paper reviews existing data on and definitions for pediatric AKI, general preventive and treatment strategies, as well as ongoing research efforts on AKI. We are hopeful that the prognosis of AKI will improve with collaboration on a multicenter, multinational scale in the form of prospective, long-term studies on pediatric AKI.
儿科急性肾损伤（AKI）的发病率正在上升。AKI 已被发现与死亡率增加独立相关，而目前的治疗选择有限，主要是支持性的。在文献中仍然可以发现各种 AKI 定义，这使得难以辨别儿科 AKI 的流行病学。使用更统一的定义是澄清 AKI 流行病学并指导我们的研究工作的必要第一步，最终将改善预后。有证据表明，新生儿和婴儿发生 AKI 的风险可能高于成年人。然而，对于这个最年轻的年龄组，研究最少，因此需要对这一人群进行更有针对性的研究。本文综述了儿科 AKI 的现有数据和定义、一般预防和治疗策略，以及 AKI 的正在进行的研究工作。我们希望通过以儿科 AKI 的前瞻性、长期研究为形式，在多中心、多国范围内进行合作，改善 AKI 的预后。
