Chair and Department of Medical Microbiology, University of Medical Sciences, Poznan, Poland.
Pol J Microbiol. 2009;58(4):301-5.
In the present work primary antimicrobial resistance was analyzed in clinical H. pylori strain isolates from adult patients from Polish Wielkopolska region within the last 10 years. Drug sensitivity was evaluated in a total of 142 H. pylori isolates, with 66 strains originating from years 1997/1998 forming group 1 and 76 strains isolated in 2007/2008 forming group 2. Sensitivity to amoxicillin, tetracycline, metronidazole and clarithromycin was determined by E-test. All strains were susceptible to amoxicillin and tetracycline. On the other hand, a high proportion of strains resistant to metronidazole was determined (36.4% in group 1 and 44.7% in group 2). In parallel, a growing tendency was discovered for resistance to clarithromycin (9.1% strains resistant in group 1 and 18.4% isolates resistant in group 2). The studies confirm the need for monitoring the drug resistance of Helicobacter pylori strains.
本研究分析了过去 10 年来自波兰大波兰省成年患者的临床幽门螺杆菌分离株的主要抗菌耐药性。共检测了 142 株幽门螺杆菌的药敏性，其中 1997/1998 年分离的 66 株菌株为第 1 组，2007/2008 年分离的 76 株菌株为第 2 组。采用 E-试验法检测阿莫西林、四环素、甲硝唑和克拉霉素的敏感性。所有菌株均对阿莫西林和四环素敏感。另一方面，耐药率较高的甲硝唑菌株比例较高（第 1 组为 36.4%，第 2 组为 44.7%）。同时，发现克拉霉素耐药性呈上升趋势（第 1 组耐药率为 9.1%，第 2 组耐药率为 18.4%）。研究证实需要监测幽门螺杆菌菌株的耐药性。
