State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Infect Genet Evol. 2010 Jul;10(5):638-44. doi: 10.1016/j.meegid.2010.03.015. Epub 2010 Apr 7.
An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages.
2003 年，中国云南省昆明市某高校（A 学院）学生中爆发肾综合征出血热。随后的调查显示，A 学院和另外两所机构的实验大鼠携带汉坦病毒抗体和抗原。在这三个地点，除了首例病例外，还在另外 15 个人身上检测到汉坦病毒抗体。流行病学数据表明，人类感染是病毒从实验大鼠向人类的动物源性传播所致。从 A 学院的大鼠中分离出一种病毒，全长基因组序列表明这是一种新的汉坦病毒分离株，命名为 KY 株。三个基因组片段的序列分析表明，这种新分离株是一种来自人源和鼠源汉坦病毒的重组体。对中（M）基因组片段的进一步序列分析表明，它起源于两个鼠源汉坦病毒谱系之间的重组事件。
