University of Limpopo (Medunsa Campus), South Africa.
Burns. 2010 Nov;36(7):1036-41. doi: 10.1016/j.burns.2010.01.016. Epub 2010 Apr 9.
Since the early 1980s a plethora of dressings has been developed to promote wound healing. The objective of this study was to compare the effects of silver based dressings and honey based dressings on cell viability.
In this blinded study, keratinocyte cultures were exposed to prepared extracts of each of the following wound dressings for 40 h: Silver based dressings: Acticoat, Actisorb, Askina, Atrauman-Ag and Contreet. Honey based dressings: Melladerm gel, Melladerm mesh, Melladerm plus and Mellarsorb. Controls consisted of cells that were cultured in the same medium, and under the same conditions as those exposed to extracts.
All dressing extracts had an effect on cell viability. Changes in cell morphology from different wound dressing extracts were noted and compared with control groups after 24 h of incubation.
In the silver based extracts group, Atrauman-silver and Acticoat had the most viable cells. For the honey based group, the most viable cells were seen with Melladerm mesh and Mellasorb. There was no significant difference between the best performing silver and honey based wound preparations with regard to cell viability.
自 20 世纪 80 年代初以来，已经开发出了大量的敷料来促进伤口愈合。本研究的目的是比较含银敷料和含蜂蜜敷料对细胞活力的影响。
在这项盲法研究中，角质细胞培养物暴露于以下每种伤口敷料的制备提取物中 40 小时：含银敷料：Acticoat、Actisorb、Askina、Atrauman-Ag 和 Contreet。含蜂蜜敷料：Melladerm 凝胶、Melladerm 网、Melladerm 加和 Mellarsorb。对照组由在与暴露于提取物相同的条件下培养的细胞组成。
所有敷料提取物都对细胞活力有影响。在孵育 24 小时后，观察到不同伤口敷料提取物对细胞形态的影响，并与对照组进行比较。
在含银提取物组中，Atrauman 银和 Acticoat 具有最具活力的细胞。对于含蜂蜜组，Melladerm 网和 Mellarsorb 中观察到最具活力的细胞。在细胞活力方面，表现最好的含银和含蜂蜜伤口制剂之间没有显著差异。
