The University Hospitals Center for Nursing and Care Research, Copenhagen, Denmark.
Wound Repair Regen. 2011 Nov;19(6):664-70. doi: 10.1111/j.1524-475X.2011.00735.x. Epub 2011 Oct 13.
Malignant wounds (MWs) occur in 5-10% of all cancer patients. Malodor and exudation are the most common side effects. The aim was to determine the influence of honey-coated compared with silver-coated bandages on treatment of MWs. Patients were randomly selected to enter either group A (honey-coated bandages) or group B (silver-coated bandages). Parameters were the following: wound size, cleanliness, malodor, exudation, and wound pain. Digital photographs, visual analog scales (VAS), and wound morphology registration were used for measurement at baseline and following the 4-week intervention. Sixty-nine patients with MWs and advanced cancer, aged 47-90 (median 65.6), were included. No statistically significant difference was noted between the groups with respect to wound size, degree of cleanliness, exudation, malodor, and wound pain. There was a median decrease in wound size of 15 cm² and 8 cm² in group A and B, respectively (p = 0.63). Based on post-intervention pooled data from the groups, improvement was seen in 62% of the participants with respect to wound size and in 58% (n = 69) with respect to cleanliness. The VAS score for malodor (p = 0.007) and exudation (p < 0.0001) improved significantly post-intervention. Patients with reduced wound size had a median survival time of 387 days compared with 134 days in patients with no wound reduction (p = 0.003). The use of honey-coated and silver-coated bandages improved the outcome of MWs. No differences were found between the two regimens. Both types of bandages are recommended for use by patients with MWs containing tumor debris and necrosis.
恶性创面（MWs）在所有癌症患者中占 5-10%。臭味和渗出是最常见的副作用。目的是确定与银涂层绷带相比，蜂蜜涂层绷带对 MWs 治疗的影响。患者被随机分为 A 组（蜂蜜涂层绷带）或 B 组（银涂层绷带）。参数如下：创面大小、清洁度、臭味、渗出和创面疼痛。基线和 4 周干预后使用数字照片、视觉模拟量表（VAS）和创面形态登记进行测量。纳入 69 例 MWs 合并晚期癌症患者，年龄 47-90 岁（中位数 65.6 岁）。两组在创面大小、清洁度、渗出、臭味和创面疼痛方面无统计学差异。A 组和 B 组的创面大小中位数分别减少了 15cm²和 8cm²（p=0.63）。根据两组干预后的汇总数据，62%的参与者的创面大小得到改善，58%（n=69）的参与者的清洁度得到改善。臭味（p=0.007）和渗出（p<0.0001）的 VAS 评分在干预后显著改善。创面缩小的患者中位生存时间为 387 天，而无创面缩小的患者中位生存时间为 134 天（p=0.003）。使用蜂蜜涂层和银涂层绷带均可改善 MWs 的预后。两种方案之间没有发现差异。建议将这两种绷带用于含有肿瘤碎屑和坏死的 MWs 患者。
