Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599-7295, USA.
Cell Mol Immunol. 2010 May;7(3):204-10. doi: 10.1038/cmi.2010.20. Epub 2010 Apr 12.
Foxp3-expressing regulatory T cells (Tregs) were originally identified as critical in maintaining self-tolerance and immune homeostasis. The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied. Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response. This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.
Foxp3 表达的调节性 T 细胞(Tregs)最初被鉴定为在维持自身耐受和免疫稳态方面具有关键作用。Tregs 的免疫抑制功能已被广泛认可,并进行了广泛研究。最近的研究揭示了 Tregs 在塑造免疫系统和炎症反应方面的许多不同作用。本综述将讨论我们以及其他人在理解 Tregs 在免疫调节中的多方面功能方面所做的努力。