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发展中国家早产儿视网膜病变的筛查标准。

Screening criteria for retinopathy of prematurity in developing countries.

作者信息

Akman Ipek, Demirel Utku, Yenice Ozlem, Ilerisoy Hacer, Kazokoğlu Haluk, Ozek Eren

机构信息

Department of Neonatology, Marmara University Hospital, Istanbul, Turkey.

出版信息

Eur J Ophthalmol. 2010 Sep-Oct;20(5):931-7. doi: 10.1177/112067211002000519.

Abstract

PURPOSE

Retinopathy of prematurity (ROP) is a serious problem which potentially can lead to blindness. The objective of this study is to detect the incidence of ROP and the number of preterm babies requiring treatment for ROP in our center and to establish the screening criteria for our country.

METHODS

A total of 801 babies with a gestational age less than 37 weeks were screened for ROP. Babies with a gestational age (GA) less than 32 weeks (n=348) were assigned as group 1. Babies with a GA between 32 and 34 weeks (n=335) were assigned as group 2 and between 35 and 37 weeks (n=98) were assigned as group 3. Clinical features and ROP screening results of the cases were documented.

RESULTS

In group 1, ROP was detected in 176 (50.9%) babies, 41 (11.8%) of whom were treated with laser/cryotherapy. In group 2, 83 (25%) cases of ROP were detected, and 11 of them (3.1%) required therapy. In group 3, 9 (9.1%) infants were diagnosed with ROP, and none of them required treatment. Clinical factors associated with ROP in group 1 were gestational age, birthweight, duration of ventilation, duration of oxygen supplementation, sepsis, and bronchopulmonary dysplasia.

CONCLUSIONS

In developing countries, the criteria for ROP screening programs should be designed according to local conditions. In our country, screening all premature babies with a gestational age less than 34 weeks or a birthweight less than 1850 g appears to be appropriate.

摘要

目的

早产儿视网膜病变(ROP)是一个严重问题,有可能导致失明。本研究的目的是检测我院ROP的发病率以及需要接受ROP治疗的早产儿数量,并制定我国的筛查标准。

方法

对801例孕周小于37周的婴儿进行ROP筛查。孕周(GA)小于32周的婴儿(n = 348)被归为第1组。GA在32至34周之间的婴儿(n = 335)被归为第2组,35至37周之间的婴儿(n = 98)被归为第3组。记录病例的临床特征和ROP筛查结果。

结果

在第1组中,176例(50.9%)婴儿检测出ROP,其中41例(11.8%)接受了激光/冷冻治疗。在第2组中,检测出83例(25%)ROP病例,其中11例(3.1%)需要治疗。在第3组中,9例(9.1%)婴儿被诊断为ROP,但均无需治疗。第1组中与ROP相关的临床因素包括孕周、出生体重、通气时间、吸氧时间、败血症和支气管肺发育不良。

结论

在发展中国家,ROP筛查项目的标准应根据当地情况制定,在我国,对所有孕周小于34周或出生体重小于1850g的早产儿进行筛查似乎是合适的。

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