Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, Granada, Spain.
Food Chem Toxicol. 2010 Jun;48(6):1425-38. doi: 10.1016/j.fct.2010.04.007. Epub 2010 Apr 10.
Anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin) are currently the most effective group of anti-neoplastic drugs used in clinical practice. Of these, doxorubicin (also called adriamycin) is a key chemotherapeutic agent in cancer treatment, although its use is limited as a consequence of the chronic and acute toxicity associated with this drug. The molecular mechanisms of doxorubicin account for both the anti-cancer and the toxic side effects. Many antioxidants have been assayed, with positive or negative results, to prevent the toxicity of doxorubicin. The present review has two main goals: (1) to report the latest findings regarding the molecular mechanisms of doxorubicin toxicity; (2) to update our understanding of the role of natural antioxidants in preventive therapy against doxorubicin-induced toxicity. This review provides new evidence for the chemoprevention of doxorubicin toxicity, making use of natural antioxidants - in particular vitamin E, vitamin C, coenzyme Q, carotenoids, vitamin A, flavonoids, polyphenol, resveratrol, antioxidant from virgin olive oil and selenium - and offers new insights into the molecular mechanisms of doxorubicin toxicity with respect to DNA damage, free radicals and other parameters.
蒽环类药物（多柔比星、柔红霉素、表柔比星和伊达比星）是目前临床实践中最有效的抗肿瘤药物之一。其中，多柔比星（也称为阿霉素）是癌症治疗中的关键化疗药物，但其应用受到限制，因为该药物具有慢性和急性毒性。多柔比星的分子机制既可以解释其抗癌作用，也可以解释其毒性作用。已经有许多抗氧化剂被检测用于预防多柔比星的毒性，但结果有阳性也有阴性。本综述有两个主要目标：（1）报告多柔比星毒性的分子机制的最新发现；（2）更新我们对天然抗氧化剂在预防多柔比星诱导的毒性中的作用的认识。本综述为利用天然抗氧化剂（特别是维生素 E、维生素 C、辅酶 Q、类胡萝卜素、维生素 A、类黄酮、多酚、白藜芦醇、初榨橄榄油中的抗氧化剂和硒）预防多柔比星毒性提供了新的证据，并为多柔比星毒性的分子机制提供了新的见解，涉及 DNA 损伤、自由基和其他参数。
