Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey.
Nutr Cancer. 2010;62(7):988-95. doi: 10.1080/01635581.2010.509838.
Antineoplastic agents induce the production of free radicals and other reactive oxygen species (ROS) in biological systems. Cytotoxic effects of antineoplastic drugs depend on rapid proliferation of cancer cells. Oxidative stress occurring during chemotherapy may potentially interfere with these effects through reducing the rate of cell proliferation. ROS may also contribute to side effects that occur with chemotherapeutic agents such as doxorubicin-induced cardiotoxicity, cisplatin-induced nephrotoxicity, and bleomycin-induced pulmonary fibrosis. Lycopene is a major carotenoid present in tomatoes, and it is a potent antioxidant that may provide protection against cellular damage caused by ROS. Lycopene may reduce or prevent the side effects of chemotherapy due to its antioxidant and anti-inflammatory properties. This review focuses on the protective effects of lycopene against antineoplastic agent induced toxicity.
抗肿瘤药物在生物系统中诱导自由基和其他活性氧物质（ROS）的产生。抗肿瘤药物的细胞毒性作用取决于癌细胞的快速增殖。化疗过程中发生的氧化应激可能会通过降低细胞增殖率来潜在地干扰这些作用。ROS 还可能导致与化疗药物相关的副作用，如多柔比星引起的心脏毒性、顺铂引起的肾毒性和博来霉素引起的肺纤维化。番茄红素是番茄中主要的类胡萝卜素，它是一种有效的抗氧化剂，可以提供对 ROS 引起的细胞损伤的保护。番茄红素可能通过其抗氧化和抗炎特性减少或预防化疗的副作用。这篇综述重点介绍了番茄红素对抗肿瘤药物诱导的毒性的保护作用。
