Niemczyk S, Ludwicka A, Groniowski M, Lewandowski Z, Hasse Z
Kliniki Chorób Wewnetrznych, AM w Warszawie.
Pol Arch Med Wewn. 1991 Jan;85(1):1-11.
The effect was studied of intraperitoneal intake of calcium on gentamicin nephrotoxicity in the rats. Two groups of Wistar were studied: G--in the first group gentamicin was injected in single daily dose 100 mg/kg b.w. subcutaneously, GCa--in the second group gentamicin was given s.c. and calcium intraperitoneal in single daily dose 45 mg Ca++/kg b.w. Results were evaluated after 3, 7, and 10 days of gentamicin injections and after ten days of gentamicin removal, Mean creatinine level after ten days of gentamicin administration was in G group 4.52 +/- 0.77 mg%, GCa--1.87 +/- 0.21 mg%, p less than 0.02, mean urea 192. 62 +/- 21.88 mg%, 77.09 +/- 8.68 mg%, p less than 0.01, serum calcium 8.39 +/- 0.15 mg%, 9.96 +/- 0.21 mg%, p less than 0.001, gentamicin in the renal cortex 384.68 +/- 67.62 micrograms/g tissue, 327.38 +/- 81.89 micrograms/g tissue p less than 0.05. Urinary calcium excretion was higher in the GCa group than in the group of control rats. Statistical differences were significant after 3 and 7 days of gentamicin intake. Differences were found also in the light and electron microscopic examination.
Intraperitoneal calcium loading significantly reduced the gentamicin nephrotoxicity in the rats and lowered gentamicin level in the renal cortex of the rats.
研究了腹腔内摄入钙对大鼠庆大霉素肾毒性的影响。研究了两组Wistar大鼠：G组，第一组大鼠每天皮下注射单次剂量100mg/kg体重的庆大霉素；GCa组，第二组大鼠皮下注射庆大霉素并腹腔内注射单次剂量45mg Ca++/kg体重的钙。在庆大霉素注射3、7和10天后以及庆大霉素停药10天后评估结果。庆大霉素给药10天后，G组的平均肌酐水平为4.52±0.77mg%，GCa组为1.87±0.21mg%，p<0.02；平均尿素水平分别为192.62±21.88mg%、77.09±8.68mg%，p<0.01；血清钙水平分别为8.39±0.15mg%、9.96±0.21mg%，p<0.001；肾皮质中的庆大霉素含量分别为384.68±67.62μg/g组织、327.38±81.89μg/g组织，p<0.05。GCa组的尿钙排泄高于对照大鼠组。在庆大霉素摄入3天和7天后，统计学差异显著。在光镜和电镜检查中也发现了差异。
腹腔内钙负荷显著降低了大鼠的庆大霉素肾毒性，并降低了大鼠肾皮质中的庆大霉素水平。
