不同种属的耐碳青霉烯类肺炎克雷伯菌中，XerC/XerD 样重组酶位点侧翼的 OXA-24 碳青霉烯酶基因存在于不同质粒中，这些菌株均分离自一次医院感染暴发。
OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak.
机构信息
Laboratorio de Microbiología, Complejo Hospitalario Universitario A Coruña, Xubias s/n, 3 Planta Ed. Sur, 15006 La Coruña, Spain.
出版信息
Antimicrob Agents Chemother. 2010 Jun;54(6):2724-7. doi: 10.1128/AAC.01674-09. Epub 2010 Apr 12.
Abstract
A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a bla(OXA-24) gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the bla(OXA-24) gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.
摘要
一株对碳青霉烯类药物耐药的鲍氏不动杆菌临床分离株来自马德里（西班牙）一家医院的一名住院患者的血培养样本，该患者感染了一种多药耐药鲍氏不动杆菌克隆株，引发了一次大规模感染（影响了 300 多名住院患者）。两种鲍曼不动杆菌和醋酸钙不动杆菌克隆的碳青霉烯类药物耐药性是由于 bla（OXA-24）基因位于不同质粒中所致。对质粒进行了全序列测序，揭示了可能参与 bla（OXA-24）基因转移的位点特异性重组结合位点。对两种菌株中含有的质粒进行比较，发现耐基因可能在不动杆菌种间发生了水平传播。
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