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Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy).与罗马（意大利）欧洲克隆型I和II相关的流行性多重耐药鲍曼不动杆菌
Clin Microbiol Infect. 2009 Apr;15(4):347-57. doi: 10.1111/j.1469-0691.2009.02668.x.
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Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.多重耐药鲍曼不动杆菌的比较基因组序列分析
J Bacteriol. 2008 Dec;190(24):8053-64. doi: 10.1128/JB.00834-08. Epub 2008 Oct 17.
3
A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital.一种质粒携带的blaOXA - 58基因赋予黎巴嫩一家医院分离出的鲍曼不动杆菌对亚胺培南的耐药性。
Antimicrob Agents Chemother. 2008 Nov;52(11):4115-20. doi: 10.1128/AAC.00366-08. Epub 2008 Aug 25.
4
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.一株属于欧洲克隆II群的流行多重耐药鲍曼不动杆菌的全基因组焦磷酸测序
Antimicrob Agents Chemother. 2008 Jul;52(7):2616-25. doi: 10.1128/AAC.01643-07. Epub 2008 Apr 14.
5
Comparative analysis of Acinetobacters: three genomes for three lifestyles.不动杆菌的比较分析：三种生活方式的三个基因组
PLoS One. 2008 Mar 19;3(3):e1805. doi: 10.1371/journal.pone.0001805.
6
Genetic diversity of carbapenem-resistant isolates of Acinetobacter baumannii in Europe.欧洲鲍曼不动杆菌碳青霉烯类耐药菌株的遗传多样性
Clin Microbiol Infect. 2008 Feb;14(2):161-7. doi: 10.1111/j.1469-0691.2007.01911.x. Epub 2007 Dec 18.
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Global challenge of multidrug-resistant Acinetobacter baumannii.多重耐药鲍曼不动杆菌的全球挑战
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8
Use of sequence-based typing and multiplex PCR to identify clonal lineages of outbreak strains of Acinetobacter baumannii.使用基于序列的分型和多重PCR来鉴定鲍曼不动杆菌暴发菌株的克隆谱系。
Clin Microbiol Infect. 2007 Aug;13(8):807-15. doi: 10.1111/j.1469-0691.2007.01759.x.
9
Outbreak of Acinetobacter baumannii producing the carbapenem-hydrolyzing oxacillinase OXA-58 in Rome, Italy.意大利罗马产碳青霉烯水解型苯唑西林酶OXA-58的鲍曼不动杆菌暴发。
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Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.鲍曼不动杆菌中碳青霉烯水解型苯唑西林酶基因blaOXA - 23的遗传学与表达
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pABVA01的特性分析，pABVA01是一种编码来自意大利鲍曼不动杆菌分离株的OXA-24碳青霉烯酶的质粒。

Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii.

作者信息

D'Andrea Marco Maria, Giani Tommaso, D'Arezzo Silvia, Capone Alessandro, Petrosillo Nicola, Visca Paolo, Luzzaro Francesco, Rossolini Gian Maria

机构信息

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Santa Maria alle Scotte, I-53100 Siena, Italy.

出版信息

Antimicrob Agents Chemother. 2009 Aug;53(8):3528-33. doi: 10.1128/AAC.00178-09. Epub 2009 Jun 1.

DOI:10.1128/AAC.00178-09
PMID:19487447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2715606/
Abstract

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

摘要

对两株在流行病学上无关联的耐碳青霉烯鲍曼不动杆菌分离株进行了研究，它们作为意大利首批产生OXA-24碳青霉烯酶的分离株的代表。两株分离株均属于欧洲克隆谱系II，且携带一个相同的编码OXA-24的质粒，命名为pABVA01。比较分析显示，在pABVA01中，bla(OXA-24)是一个DNA模块的一部分，该模块两侧是与XerC/XerD结合位点同源的保守反向重复序列，而在其他不动杆菌质粒中，这些反向重复序列位于不同的DNA模块两侧，这表明其通过一种新的位点特异性重组机制进行移动。