pABVA01的特性分析，pABVA01是一种编码来自意大利鲍曼不动杆菌分离株的OXA-24碳青霉烯酶的质粒。
Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii.
作者信息
D'Andrea Marco Maria, Giani Tommaso, D'Arezzo Silvia, Capone Alessandro, Petrosillo Nicola, Visca Paolo, Luzzaro Francesco, Rossolini Gian Maria
机构信息
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Santa Maria alle Scotte, I-53100 Siena, Italy.
出版信息
Antimicrob Agents Chemother. 2009 Aug;53(8):3528-33. doi: 10.1128/AAC.00178-09. Epub 2009 Jun 1.
Abstract
Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.
摘要
对两株在流行病学上无关联的耐碳青霉烯鲍曼不动杆菌分离株进行了研究，它们作为意大利首批产生OXA-24碳青霉烯酶的分离株的代表。两株分离株均属于欧洲克隆谱系II，且携带一个相同的编码OXA-24的质粒，命名为pABVA01。比较分析显示，在pABVA01中，bla(OXA-24)是一个DNA模块的一部分，该模块两侧是与XerC/XerD结合位点同源的保守反向重复序列，而在其他不动杆菌质粒中，这些反向重复序列位于不同的DNA模块两侧，这表明其通过一种新的位点特异性重组机制进行移动。
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