Department of Ophthalmology, New Jersey Medical School, Newark, NJ, USA.
Cornea. 2010 Jun;29(6):618-21. doi: 10.1097/ICO.0b013e3181c325b2.
To determine the prevalence of ocular surface disease (OSD) in patients with glaucoma using topical intraocular pressure (IOP)-lowering therapy.
This prospective observational study enrolled patients with primary open-angle glaucoma or ocular hypertension who were on a topical IOP-lowering medication regimen. Enrolled patients completed the ocular surface disease index (OSDI) and OSDI scores (0-100, with 0 representing no symptoms) were calculated for each patient. Medical history, demographics, and concomitant medication information were also collected.
Overall, 630 patients from 10 sites participated. Of these, 305 patients (48.4%) had an OSDI score indicating either mild (n = 134, 21.3%), moderate (n = 84, 13.3%), or severe (n = 87, 13.8%) OSD symptoms. OSDI scores were significantly different between patients with and without a prior diagnosis of dry eye syndrome (25.2 +/- 15.4 vs 15.4 +/- 15.8, respectively; P = 0.0036) and between patients who did and did not use artificial tears at the time of study participation (23.0 +/- 15.6 vs 15.3 +/- 15.8, respectively; P = 0.0046). Mean OSDI scores varied significantly with the number of topical IOP-lowering medications used, with higher (more severe) OSDI scores in patients using multiple IOP-lowering medications. Specifically, patients on a single medication had a mean OSDI score of 12.9 +/- 13.1, which was significantly lower than those of patients on 2 (16.7 +/- 17.0; P = 0.007) or 3 medications (19.4 +/- 18.1; P = 0.0001).
OSD is prevalent among medically treated patients with glaucoma. The severity of OSD symptoms is positively correlated to the number of IOP-lowering medications used.
通过评估局部眼内压（IOP）降低治疗对青光眼患者的眼表疾病（OSD）的影响，确定 OSD 的流行情况。
这是一项前瞻性观察性研究，纳入了接受局部 IOP 降低药物治疗的原发性开角型青光眼或高眼压症患者。入组患者完成眼表疾病指数（OSDI）评估，为每位患者计算 OSDI 评分（0-100 分，0 分表示无症状）。同时还收集了患者的病史、人口统计学资料和合并用药信息。
共有来自 10 个地点的 630 名患者参与了研究。其中，305 名患者（48.4%）的 OSDI 评分表明存在轻度（n=134，21.3%）、中度（n=84，13.3%）或重度（n=87，13.8%）的 OSD 症状。有或没有干眼症综合征诊断史的患者之间的 OSDI 评分存在显著差异（分别为 25.2±15.4 分和 15.4±15.8 分，P=0.0036），且在研究期间是否使用人工泪液的患者之间的 OSDI 评分也存在显著差异（分别为 23.0±15.6 分和 15.3±15.8 分，P=0.0046）。使用的局部 IOP 降低药物数量与平均 OSDI 评分显著相关，使用多种 IOP 降低药物的患者 OSDI 评分更高（更严重）。具体来说，使用单一药物的患者的平均 OSDI 评分为 12.9±13.1，明显低于使用两种（16.7±17.0；P=0.007）或三种药物（19.4±18.1；P=0.0001）的患者。
接受药物治疗的青光眼患者中 OSD 很常见。OSD 症状的严重程度与使用的 IOP 降低药物数量呈正相关。
