Eye Associates, Glaucoma Unit, Sydney Eye Hospital, Sydney, NSW 2000, Australia.
Am J Ophthalmol. 2012 Jan;153(1):1-9.e2. doi: 10.1016/j.ajo.2011.05.033. Epub 2011 Aug 26.
To investigate the relationship between ocular surface disease and glaucoma-related quality of life (QoL), glaucoma severity, and treatment in patients with open-angle glaucoma.
Cross-sectional study.
Clinical practice.
One hundred twenty-four participants-patients with mild (n = 48), moderate (n = 34), or severe (n = 19) glaucoma and 23 controls (glaucoma suspects) not receiving glaucoma treatment-were enrolled. Severity was stratified according to binocular visual field loss. OBSERVED PROCEDURES: Demographic information, the Ocular Surface Disease Index (OSDI), and Glaucoma Quality of Life-15 (GQL-15) questionnaires were administered.
OSDI score, GQL-15 score, number and type of glaucoma medications, daily dose of benzalkonium chloride (BAK), and visual field indices.
OSDI scores and the number of patients with OSD increased with increasing glaucoma severity (P < .001 and P < .005). GQL-15 scores reflected decreased QoL with increasing glaucoma severity (P < .001). These trends were maintained after sub-stratification for age and sex. On univariate regression OSDI was significantly correlated with GQL-15 summary score, glaucoma severity, multiple topical glaucoma medications, worse eye mean deviation and pattern standard deviation, use of topical beta blockers, topical carbonic anhydrase inhibitors, daily dose of BAK, and glaucoma filtration surgery. On multivariate regression GQL-15 summary score (odds ratio [OR] 4.14, 95% confidence interval [CI] 2.59-6.63, P < .001) and a daily dose of BAK greater than 3 (OR 2.47, 95% CI 1.17-5.21, P = .018) were predictive of OSDI score.
OSD is more common in patients with increasing glaucoma severity and is associated with poorer glaucoma-related QoL and higher exposure to BAK.
研究眼表疾病与开角型青光眼患者的青光眼相关生活质量（QoL）、青光眼严重程度和治疗之间的关系。
横断面研究。
临床实践。
共纳入 124 名参与者-轻度（n=48）、中度（n=34）或重度（n=19）青光眼患者和 23 名未接受青光眼治疗的青光眼疑似患者（对照组）。根据双眼视野损失对严重程度进行分层。
记录人口统计学信息、眼表疾病指数（OSDI）和青光眼生活质量-15 项（GQL-15）问卷评分。
OSDI 评分、GQL-15 评分、青光眼药物的种类和数量、每日苯扎氯铵（BAK）剂量以及视野指数。
随着青光眼严重程度的增加，OSDI 评分和患有 OSD 的患者数量也随之增加（P<0.001 和 P<0.005）。GQL-15 评分反映了随着青光眼严重程度的增加 QoL 下降（P<0.001）。这些趋势在按年龄和性别进行细分后仍保持不变。在单变量回归中，OSDI 与 GQL-15 综合评分、青光眼严重程度、多种局部青光眼药物、较差眼平均偏差和模式标准差、局部β受体阻滞剂的使用、局部碳酸酐酶抑制剂、每日 BAK 剂量和青光眼滤过手术显著相关。在多变量回归中，GQL-15 综合评分（优势比[OR]4.14，95%置信区间[CI]2.59-6.63，P<0.001）和 BAK 每日剂量大于 3（OR 2.47，95%CI 1.17-5.21，P=0.018）是 OSDI 评分的预测因素。
随着青光眼严重程度的增加，眼表疾病更为常见，与青光眼相关的 QoL 更差，并且接触 BAK 的频率更高。
