[MRI scan of striatum volume in healthy adults].

作者信息

Xu Jing-feng, Xu Xiao-jun, Wang Qi-dong, Zhao Yi-lei, Kong De-xing, Zhang Min-ming

机构信息

Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Mar;39(2):130-5. doi: 10.3785/j.issn.1008-9292.2010.02.004.

DOI:10.3785/j.issn.1008-9292.2010.02.004

PMID:20387239

Abstract

OBJECTIVE

To examine the age, sex, and hemispheric differences in volume of the striatum by MRI in healthy adults.

METHODS

The volumes of the bilateral caudate nucleus and putamen were measured on MR images in 100 healthy right-handed adults (18-70 y).

RESULTS

The volume of bilateral caudate nucleus and putamen in healthy adults was (8.42 +/-0.88) cm(3) and (8.90 +/-0.89) cm(3), which were decreased with aging (for caudate nucleus r=-0.727, P<0.001; for putamen r=-0.709, P<0.001). The average annual shrinkage rate was 0.52 % in the caudate nucleus and 0.50 % in the putamen. There were no gender differences in the volume of the striatum, however, the age-related shrinkage of the striatum was more evident in men than that in women. The volume of the left caudate nucleus (t=4.43, P<0.001) and the putamen (t=4.88, P<0.001) was greater than that of its right counterpart.

CONCLUSION

Bilateral age-related shrinkage of the striatum is found in healthy adults, which is more evident in men than that in women. In both sexes, significant leftward asymmetry in volume of the caudate nucleus and the putamen is found.

摘要