Bauta Dental Teaching Clinic, Havana, Cuba.
MEDICC Rev. 2010 Winter;12(1):24-8. doi: 10.37757/MR2010.V12.N1.5.
Dentin hypersensitivity (DH) is a painful tooth condition affecting a large proportion of the world population. While DH is not a direct cause of tooth loss, it does cause discomfort and stress. DH treatment methods include desensitizers, such as fluoride compounds; polycyanoacrylate coating; low intensity laser therapy; and surgery as a last resort. In Cuba, a fluoride varnish, Profilac, is widely used with acceptable results. Tisuacryl, an N-butyl-2-cyanoacrylate-based tissue adhesive is licensed in Cuba as a medical device used for closing wounds and as a protective covering or dressing for oral tissues. Experimental use of Tisuacryl in DH treatment has begun recently with good results.
Evaluate the effectiveness and safety of Tisuacryl in treating dentin hypersensitivity.
An experimental, prospective, longitudinal, multicenter, non-controlled clinical investigation was conducted using the licensed medical device Tisuacryl. The study universe consisted of patients with DH symptoms who sought treatment at three dental clinics in Havana Province between May 2007 and February 2009. The sample consisted of 152 patients who met inclusion and diagnostic criteria for the study. DH was classified as severe, moderate, or mild. Remission of dentinal pain was the principal variable for evaluating effectiveness. Safety variables were mucosal irritation and burning sensation at the treatment site. Treatment was considered successful if DH was cured, defined as remission of pain and relief of discomfort (irritation or burning sensation) with no other adverse events by the final evaluation on day 6 after treatment initiation.
Tisuacryl treatment was successful in 96.7% of patients (81.5% with severe DH and 100% with mild to moderate DH). Mucosal irritation was observed in only 1 patient at first evaluation on day 2 but disappeared by the second evaluation. No other adverse events were reported.
Tisuacryl was shown to be an effective, safe treatment of dentin hypersensitivity, especially moderate and mild cases.
牙本质过敏（DH）是一种影响世界上很大一部分人口的痛苦牙齿状况。虽然 DH 不是牙齿缺失的直接原因，但它确实会引起不适和压力。DH 的治疗方法包括脱敏剂，如氟化物化合物；聚氰基丙烯酸酯涂层；低强度激光治疗；以及作为最后手段的手术。在古巴，氟化物清漆 Profilac 被广泛使用，效果可接受。Tisuacryl 是一种基于 N-丁基-2-氰基丙烯酸酯的组织粘合剂，在古巴被许可为医疗器械，用于闭合伤口，以及口腔组织的保护覆盖物或敷料。最近开始将 Tisuacryl 用于 DH 治疗的实验性应用取得了良好的效果。
评估 Tisuacryl 治疗牙本质过敏的有效性和安全性。
使用许可的医疗器械 Tisuacryl 进行了一项实验性、前瞻性、纵向、多中心、非对照的临床研究。研究范围包括 2007 年 5 月至 2009 年 2 月期间在哈瓦那省三家牙科诊所寻求治疗的有 DH 症状的患者。该样本由 152 名符合研究纳入和诊断标准的患者组成。DH 分为严重、中度和轻度。评估有效性的主要变量是牙本质疼痛的缓解。安全性变量是治疗部位的粘膜刺激和烧灼感。如果 DH 被治愈，即疼痛缓解和不适（刺激或烧灼感）缓解，在治疗开始后第 6 天的最终评估中没有其他不良事件，则认为治疗是成功的。
Tisuacryl 治疗在 96.7%的患者中（严重 DH 患者为 81.5%，轻度至中度 DH 患者为 100%）成功。只有 1 名患者在第 2 天的第一次评估中观察到粘膜刺激，但在第二次评估时消失。没有其他不良事件报告。
Tisuacryl 被证明是一种有效的、安全的牙本质过敏治疗方法，特别是对中度和轻度病例。
