Department of Pediatrics, General Hospital Subotica, Izvorska 3, 24000 Subotica, Serbia.
J Trop Pediatr. 2010 Dec;56(6):443-5. doi: 10.1093/tropej/fmq026. Epub 2010 Apr 13.
The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.
唐氏综合征（DS）和乳糜泻（CD）共存的情况在许多研究中都有报道。在我们的研究中，我们使用血清学标志物免疫球蛋白 A（IgA）和免疫球蛋白 G（IgG）转谷氨酰胺酶抗体检查了 82 名年龄在 8 个月至 8.6 岁的 DS 儿童，以确定是否存在 CD，随后检测了总 IgA 水平。在上述抗体之一呈阳性的 4 名儿童中，进行了肠活检，结果显示无 CD。我们的研究结果对 8 岁以下 DS 儿童是否需要强制性进行血清学筛查提出了质疑。
