Wilms K
Medizinische Poliklinik, Universität Würzburg.
Z Gesamte Inn Med. 1991 Mar;46(3):53-8.
Pre-stages and early stages of malignant Non-Hodgkin's-lymphomas mark the border area between benign, reactive lymphoproliferation and neoplastic transformation. The advances of immunological classification of lymphoid cells with monoclonal antibodies and molecular genetic analysis have contributed to our present knowledge of pathomorphology, pathophysiology and nosology of malignant lymphomas. The stepwise evolution between polyclonal reactive lymphoproliferation and clonal autonomous growth in malignant lymphomas are presented by discussion of the mucosa-associated lymphomas (MALT-lymphomas) and typical lymphoproliferative diseases.
恶性非霍奇金淋巴瘤的前期和早期标志着良性反应性淋巴细胞增生与肿瘤性转化之间的交界区域。利用单克隆抗体对淋巴细胞进行免疫分类以及分子遗传学分析的进展，促进了我们目前对恶性淋巴瘤病理形态学、病理生理学和疾病分类学的认识。通过对黏膜相关淋巴瘤（MALT淋巴瘤）和典型淋巴细胞增生性疾病的讨论，阐述了恶性淋巴瘤中多克隆反应性淋巴细胞增生与克隆自主性生长之间的逐步演变过程。
