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用于800纳米和1060纳米视网膜成像的快速色散编码全范围光学相干断层扫描技术

Fast dispersion encoded full range optical coherence tomography for retinal imaging at 800 nm and 1060 nm.

作者信息

Hofer Bernd, Povazay Boris, Unterhuber Angelika, Wang Ling, Hermann Boris, Rey Sara, Matz Gerald, Drexler Wolfgang

机构信息

Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

出版信息

Opt Express. 2010 Mar 1;18(5):4898-919. doi: 10.1364/OE.18.004898.

Abstract

The dispersion mismatch between sample and reference arm in frequency-domain optical coherence tomography (OCT) can be used to iteratively suppress complex conjugate artifacts and thereby increase the imaging range. In this paper, we propose a fast dispersion encoded full range (DEFR) algorithm that detects multiple signal components per iteration. The influence of different dispersion levels on the reconstruction quality is analyzed experimentally using a multilayered scattering phantom and in vivo retinal tomograms at 800 nm. Best results have been achieved with 30 mm SF11, with neglectable resolution decrease due to finite resolution of the spectrometer. Our fast DEFR algorithm achieves an average suppression ratio of 55 dB and typically converges within 5 to 10 iterations. The processing time on non-dedicated hardware was 5 to 10 seconds for tomograms with 512 depth scans and 4096 sampling points per depth scan. Application of DEFR to the more challenging 1060 nm wavelength region is also demonstrated by introducing an additional optical fibre in the sample arm.

摘要

频域光学相干断层扫描(OCT)中样本臂和参考臂之间的色散失配可用于迭代抑制复共轭伪像,从而增加成像范围。在本文中,我们提出了一种快速色散编码全范围(DEFR)算法,该算法每次迭代可检测多个信号分量。使用多层散射体模和800nm的体内视网膜断层图像,通过实验分析了不同色散水平对重建质量的影响。使用30mm的SF11取得了最佳结果,由于光谱仪的有限分辨率导致的分辨率下降可忽略不计。我们的快速DEFR算法实现了55dB的平均抑制率,通常在5到10次迭代内收敛。对于具有512次深度扫描且每次深度扫描有4096个采样点的断层图像,在非专用硬件上的处理时间为5到10秒。通过在样本臂中引入额外的光纤,还展示了DEFR在更具挑战性的1060nm波长区域的应用。

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