钝叶波罗蜜中的两种新呫吨酮。

Two new xanthones from Artocarpus obtusus.

作者信息

Hashim Najihah, Rahmani Mawardi, Sukari Mohd A, Ali Abdul M, Alitheen Noorjahan B, Go Rosea, Ismail Hazar B M

机构信息

Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Selangor, Malaysia.

出版信息

J Asian Nat Prod Res. 2010 Feb;12(2):106-12. doi: 10.1080/10286020903450411.

DOI:10.1080/10286020903450411

PMID:20390751

Abstract

Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.

摘要

通过色谱分离从钝叶波罗蜜（Artocarpus obtusus Jarrett）的茎皮中分离出两种新的呫吨酮，即吡喃环波罗蜜呫吨酮A（1）和二氢波罗蜜宁C（2）。通过光谱方法并与已知相关化合物进行比较确定了它们的结构。采用DPPH法，吡喃环波罗蜜呫吨酮A（1）显示出较强的自由基清除活性，同时对K562、HL-60和MCF7细胞系具有细胞毒性。